Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Serine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.36 |
| ▸ | GSR | P00390 | 2/20 | 0.36 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.36 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Serine SCHEMBL1514152 | 0.94 | BHMT (0.45) | BHMTSLC1A1SLC1A3SLC1A2GRIK1 | |
| Serine SCHEMBL27873098 | 0.94 | BHMT (0.45) | BHMTSLC1A1SLC1A3SLC1A2GRIK1 | |
| Serine SCHEMBL4851695 | 0.92 | PTGS1 (0.50) | BHMTSLC1A1GLRA1SLC6A9OR51E2 | |
| Serine SCHEMBL4887749 | 0.86 | PTGS1 (0.55) | BHMTSLC1A1SLC1A3SLC1A2GRIK1 | |
| Serine SCHEMBL7925095 | 0.84 | GLRA1 (0.53) | SLC1A1GLRA1SLC6A9OR51E2SLC1A3 | |
| Serine SCHEMBL18152976 | 0.84 | GLRA1 (0.53) | SLC1A1GLRA1SLC6A9OR51E2SLC1A3 | |
| Serine SCHEMBL1064691 | 0.84 | GLRA1 (0.53) | SLC1A1GLRA1SLC6A9OR51E2SLC1A3 | |
| Serine SCHEMBL5271398 | 0.84 | GLRA1 (0.53) | SLC1A1GLRA1SLC6A9OR51E2SLC1A3 | |
| Serine SCHEMBL20511092 | 0.84 | GLRA1 (0.53) | SLC1A1GLRA1SLC6A9OR51E2SLC1A3 | |
| Serine SCHEMBL12500456 | 0.84 | GLRA1 (0.53) | SLC1A1GLRA1SLC6A9OR51E2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154803-B1 | IMMOBILIZED LABELING COMPOUNDS AND METHODS | BRACCO INT BV (NL) | 2004-11-17 | — | — | EP | disclosed |