Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926405 | 0.87 | HSD17B10 (0.51) | HPGDHSD17B10PKMATMGAA | |
| SCHEMBL27797713 | 0.83 | ATM (0.47) | HPGDHSD17B10PKMATMSMN1; SMN2 | |
| SCHEMBL1059718 | 0.81 | HPGD (0.74) | HPGDHSD17B10PKMALDH1A1KDM4E | |
| SCHEMBL7281705 | 0.77 | HSD17B10 (0.52) | HSD17B10PKMATML3MBTL1SMN1; SMN2 | |
| SCHEMBL2043767 | 0.77 | TP53 (0.55) | HPGDHSD17B10GAATP53ALOX12 | |
| SCHEMBL1058945 | 0.77 | HPGD (1.00) | HPGDGAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4651014 | 0.76 | HSD17B10 (0.51) | HSD17B10PKMATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL4407303 | 0.75 | HPGD (0.57) | HPGDPKMSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6031290 | 0.75 | KDM4E (0.49) | HPGDHSD17B10GAAL3MBTL1TP53 | |
| SCHEMBL7053350 | 0.75 | HSD17B10 (0.52) | HSD17B10PKMATML3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735445-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2014-05-27 | — | — | US | disclosed |
| US-8735445-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2014-05-27 | — | — | US | disclosed |
| EP-1594438-B1 | Use of an inhibitor of 15-hydroxyprostaglandin dehydrogenase in order to stimulate pigmentation of the skin or hair | OREAL (FR) | 2013-07-17 | — | — | EP | disclosed |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | L'OREAL (FR) | 2011-01-20 | — | — | US | disclosed |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | L'OREAL (FR) | 2011-01-20 | — | — | US | disclosed |
| US-7705041-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2010-04-27 | — | — | US | disclosed |
| US-7705041-B2 | Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages | L'OREAL (FR) | 2010-04-27 | — | — | US | disclosed |
| US-20080249117-A1 | METHODS FOR STIMULATING OR INDUCING THE GROWTH AND/OR REDUCING THE LOSS OF KERATINOUS FIBERS | SOCIETE LOREAL S.A. (FR) | 2008-10-09 | — | — | US | disclosed |
| US-20080249117-A1 | METHODS FOR STIMULATING OR INDUCING THE GROWTH AND/OR REDUCING THE LOSS OF KERATINOUS FIBERS | SOCIETE LOREAL S.A. (FR) | 2008-10-09 | — | — | US | disclosed |
| US-20080206320-A1 | COMPOSITION COMPRISING AT LEAST ONE 15-PGDH INHIBITOR | SOCIETE L'OREAL S.A. (FR) | 2008-08-28 | — | — | US | disclosed |
| US-20080206320-A1 | COMPOSITION COMPRISING AT LEAST ONE 15-PGDH INHIBITOR | SOCIETE L'OREAL S.A. (FR) | 2008-08-28 | — | — | US | disclosed |
| US-20080206320-A1 | COMPOSITION COMPRISING AT LEAST ONE 15-PGDH INHIBITOR | SOCIETE L'OREAL S.A. (FR) | 2008-08-28 | — | — | US | disclosed |
| US-7320967-B2 | Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair | L'OREAL (FR) | 2008-01-22 | — | — | US | disclosed |
| US-7320967-B2 | Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair | L'OREAL (FR) | 2008-01-22 | — | — | US | disclosed |
| US-7320967-B2 | Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair | L'OREAL (FR) | 2008-01-22 | — | — | US | disclosed |
| EP-1594438-A2 | USE OF AN INHIBITOR OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE IN ORDER TO STIMULATE PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | L'OREAL (FR) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004073594-A2 | USE OF AN INHIBITOR OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE IN ORDER TO STIMULATE PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | L'OREAL (FR) | 2004-09-02 | — | — | WO | disclosed |
| US-20040052760-A1 | Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair | SOCIETE L'OREAL S.A. (FR) | 2004-03-18 | — | — | US | disclosed |
| WO-2003090699-A1 | COSMETIC COMPOSITION FOR PROMOTING HAIR GROWTH AND/OR PREVENTING OR DELAYING HAIR LOSS | L'OREAL (FR) | 2003-11-06 | — | — | WO | disclosed |
| EP-1358868-A2 | Cosmetic composition for increasing hair growth and/or for preventing or delaying hair loss | L'OREAL (FR) | 2003-11-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040052760-A1 | Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair | HPGD, HSD17B1, HSD17B2 | HPGD 1/4885HSD17B10 6/4885PKM 1600/4885 |
| US-20080206320-A1 | COMPOSITION COMPRISING AT LEAST ONE 15-PGDH INHIBITOR | HPGD, GCDH, HSD17B1 | HPGD 1/4885HSD17B10 10/4885PKM 1830/4885 |
| US-20080249117-A1 | METHODS FOR STIMULATING OR INDUCING THE GROWTH AND/OR REDUCING THE LOSS OF KERATINOUS FIBERS | HPGD, KRT18, HSD17B1 | HPGD 1/4885HSD17B10 17/4885PKM 732/4885 |
| US-20110014250-A1 | INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES | COX15, HPGD, TYR | HPGD 2/4885HSD17B10 138/4885PKM 1622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.