Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778197 | 0.79 | HSD17B10 (0.61) | HSD17B10PKMATMALDH1A1SMN1; SMN2 | |
| SCHEMBL18839696 | 0.76 | PKM (0.74) | HSD17B10PKMATMALDH1A1TP53 | |
| SCHEMBL4852197 | 0.75 | HPGD (0.62) | HSD17B10PKMATMALDH1A1TP53 | |
| SCHEMBL7053357 | 0.74 | PKM (0.59) | HSD17B10PKMATMALDH1A1L3MBTL1 | |
| SCHEMBL4651014 | 0.73 | HSD17B10 (0.51) | HSD17B10PKMATMALDH1A1SMN1; SMN2 | |
| SCHEMBL1775696 | 0.72 | PKM (0.63) | HSD17B10PKMATMALDH1A1TP53 | |
| SCHEMBL7281705 | 0.72 | HSD17B10 (0.52) | HSD17B10PKMATMALDH1A1L3MBTL1 | |
| SCHEMBL14145932 | 0.70 | PKM (0.79) | HSD17B10PKMATMALDH1A1TP53 | |
| SCHEMBL112999 | 0.69 | ALDH1A1 (0.68) | PKMALDH1A1L3MBTL1SMN1; SMN2TSHR | |
| Benzene SCHEMBL28160801 | 0.69 | ALDH1A1 (0.68) | PKMALDH1A1L3MBTL1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301474-A2 | TYROSINE DERIVATIVES AS PHOSPHATASE INHIBITORS | Array Biopharma Inc. (US) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004412-A2 | TYROSINE DERIVATIVES AS PHOSPHATASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2002-01-17 | — | — | WO | disclosed |