Sugi Predict

Sugi Predict / Compounds / SCHEMBL4852573

SCHEMBL4852573

SCHEMBL4852573

N#Cc1cc(NCc2ccccn2)n(-c2c(Cl)cc(C(F)(F)F)cc2Cl)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 2/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ MEN1 O00255 2/20 0.42
▸ KMT2A Q03164 2/20 0.42
▸ PPARG P37231 1/20 0.42
▸ NR2E3 Q9Y5X4 1/20 0.42
▸ NCOR2 Q9Y618 1/20 0.42
▸ ALDH1A1 P00352 6/20 0.39
▸ KDM4E B2RXH2 4/20 0.39
▸ IL1B P01584 1/20 0.39
▸ GABRP O00591 4/20 0.39
▸ GABRD O14764 4/20 0.39
▸ GABRA1 P14867 4/20 0.39
▸ GABRB1 P18505 4/20 0.39
▸ GABRG2 P18507 4/20 0.39
▸ GABRB3 P28472 4/20 0.39
▸ GABRA5 P31644 4/20 0.39
▸ GABRA3 P34903 4/20 0.39
▸ GABRA2 P47869 4/20 0.39
▸ GABRB2 P47870 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5220202 0.87 GABRB3 (0.42) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL4033423 0.82 GABRB3 (0.40) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL4855148 0.80 GABRP (0.41) RAB9ANPC1MEN1KMT2APPARG
Pyriprole SCHEMBL29422238 0.80 GABRP (0.41) RAB9ANPC1MEN1KMT2APPARG
Pyriprole SCHEMBL27011 0.80 GABRP (0.41) RAB9ANPC1MEN1KMT2APPARG
SCHEMBL14208660 0.78 GABRP (0.39) RAB9ANPC1MEN1KMT2APPARG
SCHEMBL14208642 0.78 GABRP (0.39) RAB9ANPC1MEN1KMT2APPARG
SCHEMBL1750983 0.73 GABRP (0.39) RAB9ANPC1MEN1KMT2APPARG
SCHEMBL28073555 0.73 GABRB3 (0.46) GABRPGABRDGABRA1GABRB1GABRG2
Pyriprole SCHEMBL19032727 0.72 GABRP (0.35) RAB9ANPC1MEN1KMT2APPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7371768-B2 Pyrazol derivatives, pest control agent comprising the same as active ingredient, and process for producing the same NIHON NOHYAKU CO., LTD. (JP) 2008-05-13 — — US disclosed
US-7371768-B2 Pyrazol derivatives, pest control agent comprising the same as active ingredient, and process for producing the same NIHON NOHYAKU CO., LTD. (JP) 2008-05-13 — — US disclosed
EP-1310497-B1 PYRAZOLE DERIVATIVE, PEST CONTROL AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT AND PROCESS FOR PRODUCING THE SAME NIHON NOHYAKU CO LTD (JP) 2006-03-01 — — EP disclosed
US-20040053969-A1 Pyrazol derivatives, pest control agent comprising the same as active ingredient, and process for producing the same NIHON NOHYAKU CO., LTD. (JP) 2004-03-18 — — US disclosed
EP-1310497-A1 PYRAZOLE DERIVATIVES, PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT AND PROCESS FOR THEIR PRODUCTION Nihon Nohyaku Co., Ltd. (JP) 2003-05-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040053969-A1 Pyrazol derivatives, pest control agent comprising the same as active ingredient, and process for producing the same CTRL, AADAC, CBR3 RAB9A 1148/4885NPC1 2012/4885MEN1 4636/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.