Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NMT2 | O60551 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847450 | 0.94 | SLC6A9 (0.43) | HRH1SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4852365 | 0.89 | HRH1 (0.41) | HRH1SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4854182 | 0.89 | HRH1 (0.41) | HRH1SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4854470 | 0.88 | KDM4E (0.43) | HRH1SLC6A9KDM4EALDH1A1NMT2 | |
| SCHEMBL4854695 | 0.87 | SLC6A9 (0.43) | HRH1SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4847435 | 0.87 | SLC6A9 (0.46) | HRH1SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4853568 | 0.87 | SLC6A9 (0.46) | HRH1SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4849688 | 0.86 | SLC6A9 (0.41) | SLC6A9KDM4EALDH1A1SMN1; SMN2BCHE | |
| SCHEMBL4852335 | 0.86 | SLC6A9 (0.40) | HRH1SLC6A9KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4853580 | 0.86 | SLC6A9 (0.40) | HRH1SLC6A9KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |