Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL484707 | 0.86 | DPP4 (0.45) | HSP90AA1DPP4KMT2AMEN1MAPT | |
| SCHEMBL485062 | 0.84 | HSP90AA1 (0.42) | HSP90AA1KMT2AMEN1RAB9ACNR2 | |
| SCHEMBL485191 | 0.83 | HSP90AA1 (0.44) | HSP90AA1DPP4KMT2AMEN1PPARG | |
| SCHEMBL4443109 | 0.79 | CYP3A4 (0.56) | HSP90AA1KMT2ACYP3A4MEN1MAPT | |
| SCHEMBL1010013 | 0.79 | HSP90AA1 (0.41) | HSP90AA1DPP4KMT2ACYP3A4MEN1 | |
| SCHEMBL6504941 | 0.76 | MAPT (0.44) | KMT2AMEN1MAPTRAB9ATAS1R3 | |
| SCHEMBL11558507 | 0.74 | HPGD (0.50) | KMT2ACYP3A4MEN1MAPTRAB9A | |
| SCHEMBL3065007 | 0.73 | ALDH1A1 (0.45) | KMT2ACYP3A4RAB9ACYP1A2CYP2C9 | |
| SCHEMBL485234 | 0.70 | MAPT (0.45) | HSP90AA1KMT2AMEN1MAPTALOX15 | |
| SCHEMBL10652795 | 0.70 | LMNA (0.40) | KMT2AMEN1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314132-B2 | 5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof | BIOTECHNOLOGIJOS INSTITUTAS (LT) | 2012-11-20 | — | — | US | claimed |
| EP-2268626-B1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | BIOTECHNOLOGIJOS INST (LT) | 2012-02-01 | — | — | EP | claimed |
| US-20110046387-A1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | BIOTECHNOLOGIJOS INSTITUTAS (LT) | 2011-02-24 | — | — | US | claimed |
| EP-2268626-A1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | Biotechnologijos Institutas (LT) | 2011-01-05 | — | — | EP | claimed |
| WO-2009134110-A1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | BIOTECHNOLOGIJOS INSTITUTAS (LT) | 2009-11-05 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046387-A1 | 5-ARYL-4-(5-SUBSTITUTED 2,4-DIHYDROXYPHENYL)-1,2,3-THIADIAZOLES AS INHIBITORS OF HSP90 CHAPERONE AND THE INTERMEDIATES FOR PRODUCTION THEREOF | HSP90AB1, HSP90AB2P, HSP90AA1 | HSP90AA1 3/4885DPP4 3147/4885KMT2A 4472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.