Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854223 | 1.00 | MCL1 (0.53) | MCL1SNCAMAOBMAPTMAPK1 | |
| SCHEMBL4847824 | 0.90 | TUBB1 (0.55) | MCL1MAPTKMT2ABCHEACHE | |
| SCHEMBL4853445 | 0.90 | TUBB1 (0.55) | MCL1MAPTKMT2ABCHEACHE | |
| SCHEMBL4851370 | 0.89 | MCL1 (0.48) | MCL1MAOBKMT2ABCHEACHE | |
| SCHEMBL4847316 | 0.89 | MCL1 (0.48) | MCL1MAOBKMT2ABCHEACHE | |
| SCHEMBL4856299 | 0.87 | MCL1 (0.50) | MCL1SNCAMAOBKMT2ABCHE | |
| SCHEMBL4854973 | 0.87 | MCL1 (0.50) | MCL1SNCAMAOBKMT2ABCHE | |
| SCHEMBL4850004 | 0.83 | TUBB4A (0.55) | MCL1MAOBMAPTKMT2ABCHE | |
| SCHEMBL4854901 | 0.83 | TUBB4A (0.55) | MCL1MAOBMAPTKMT2ABCHE | |
| SCHEMBL4853546 | 0.80 | SNCA (0.48) | SNCABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |