Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | P4HB | P07237 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847832 | 0.90 | ABCG2 (0.46) | SNCABCHEACHEKDM4EGAA | |
| SCHEMBL4847320 | 0.89 | SNCA (0.44) | SNCABCHEACHEP4HBPTPN1 | |
| SCHEMBL4854982 | 0.87 | KDM4E (0.47) | SNCABCHEACHEKDM4EGAA | |
| SCHEMBL4850027 | 0.82 | TNFRSF1A (0.47) | SNCABCHEACHEKDM4EALDH1A1 | |
| SCHEMBL4854223 | 0.80 | MCL1 (0.53) | SNCABCHEACHE | |
| SCHEMBL4853541 | 0.80 | MCL1 (0.53) | SNCABCHEACHE | |
| SCHEMBL4847755 | 0.79 | TNFRSF1A (0.46) | SNCAPTPN1THRATHRB | |
| SCHEMBL4855883 | 0.78 | HPGD (0.52) | KDM4EGAAALDH1A1PTPN1 | |
| SCHEMBL4847119 | 0.77 | SNCA (0.41) | SNCABCHEACHEPTPN1DPP4 | |
| SCHEMBL4855130 | 0.77 | ABCB1 (0.47) | BCHEACHEKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |