Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 9/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847320 | 0.91 | SNCA (0.44) | TNFRSF1ASNCAPTPN1THRATHRB | |
| SCHEMBL4847832 | 0.89 | ABCG2 (0.46) | TNFRSF1AABCG2CAPN1SNCATUBB1 | |
| SCHEMBL4847433 | 0.89 | TNFRSF1A (0.46) | TNFRSF1AABCG2MCHR1CAPN1SNCA | |
| SCHEMBL4856242 | 0.88 | BCHE (0.45) | TNFRSF1ARELAABCG2 | |
| SCHEMBL6386830 | 0.87 | ABCG2 (0.52) | TNFRSF1AABCG2PTPN1 | |
| SCHEMBL4853345 | 0.86 | RELA (0.48) | TNFRSF1ARELAPTPN1 | |
| SCHEMBL4852218 | 0.85 | CAPN1 (0.50) | TNFRSF1ACAPN1PTPN1 | |
| SCHEMBL4849986 | 0.85 | BCHE (0.46) | TNFRSF1AABCG2CAPN1PTPN1 | |
| SCHEMBL14280884 | 0.85 | BCHE (0.46) | TNFRSF1AABCG2CAPN1PTPN1 | |
| SCHEMBL4849921 | 0.84 | BCHE (0.45) | TNFRSF1APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |