Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | CCR2 | P41597 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573912 | 0.83 | CCR2 (0.70) | ALDH1A1CCR2MAPTHTTNPSR1 | |
| SCHEMBL7571186 | 0.82 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2TP53NPC1TSHR | |
| SCHEMBL9930953 | 0.80 | CCR2 (0.64) | ALDH1A1CCR2MAPTHTTNPSR1 | |
| SCHEMBL6362814 | 0.78 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2TP53MAPTHTT | |
| SCHEMBL29684778 | 0.78 | CCR2 (0.57) | ALDH1A1SMN1; SMN2CCR2TP53MAPT | |
| SCHEMBL8752483 | 0.78 | ERBB2 (0.62) | ALDH1A1SMN1; SMN2CCR2TP53MAPT | |
| SCHEMBL9931292 | 0.78 | CCR2 (0.69) | ALDH1A1SMN1; SMN2CCR2TP53 | |
| SCHEMBL18104339 | 0.77 | KMT2A (0.76) | ALDH1A1SMN1; SMN2TP53MAPTHTT | |
| SCHEMBL21771101 | 0.77 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2TP53MAPTHTT | |
| SCHEMBL7571540 | 0.77 | SMN1; SMN2 (0.80) | ALDH1A1SMN1; SMN2CCR2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | ALDH1A1 3257/4885SMN1; SMN2 3562/4885CCR2 4304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.