Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL486058 | 0.98 | MAPT (0.52) | RAB9AL3MBTL1MAPTDRD4KLK7 | |
| SCHEMBL485779 | 0.86 | DRD4 (0.48) | RAB9AL3MBTL1MAPTDRD4ALDH1A1 | |
| Bicarbonate SCHEMBL486033 | 0.84 | GAA (0.48) | RAB9AMAPTDRD4ALDH1A1KDM4E | |
| SCHEMBL485313 | 0.79 | CXCR2 (0.52) | RAB9AMAPTKDM4ENPC1MEN1 | |
| SCHEMBL485335 | 0.78 | CXCR2 (0.58) | RAB9AL3MBTL1MAPTKDM4ENPC1 | |
| SCHEMBL485444 | 0.76 | PYGL (0.42) | RAB9AMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL485442 | 0.76 | PYGL (0.42) | RAB9AMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL28797613 | 0.72 | APP (0.51) | L3MBTL1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL29481000 | 0.71 | NPC1 (0.58) | RAB9AL3MBTL1MAPTALDH1A1KDM4E | |
| SCHEMBL67733 | 0.71 | NPC1 (0.58) | RAB9AL3MBTL1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |