Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.61 |
| ▸ | NPC1 | O15118 | 12/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.61 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.61 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | NOS3 | P29474 | 4/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.53 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NOS1 | P29475 | 2/20 | 0.51 |
| ▸ | NOS2 | P35228 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862366 | 0.83 | NPC1 (0.57) | RAB9ANPC1CDK5CDK5R1PAX8 | |
| SCHEMBL4854739 | 0.80 | NOS3 (0.55) | RAB9ANPC1CDK5CDK5R1ALDH1A1 | |
| SCHEMBL4860972 | 0.79 | NOS1 (0.58) | RAB9ANPC1CDK5CDK5R1PAX8 | |
| SCHEMBL5594064 | 0.77 | KDM4E (0.50) | RAB9ANPC1CDK5CDK5R1PAX8 | |
| SCHEMBL4861200 | 0.76 | NOS3 (0.58) | RAB9ANPC1CDK5CDK5R1PAX8 | |
| SCHEMBL9212813 | 0.75 | MAPT (0.48) | RAB9ANPC1CDK5CDK5R1PAX8 | |
| SCHEMBL9209871 | 0.75 | MAPT (0.48) | RAB9ANPC1CDK5CDK5R1PAX8 | |
| SCHEMBL9596268 | 0.73 | NOS3 (0.46) | RAB9ANPC1CDK5CDK5R1PAX8 | |
| SCHEMBL9596263 | 0.73 | NOS3 (0.46) | RAB9ANPC1CDK5CDK5R1PAX8 | |
| SCHEMBL5423613 | 0.73 | NOS3 (0.68) | RAB9ANPC1CDK5CDK5R1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018045104-A1 | ANTI-PARASITIC COMPOUNDS | OHIO STATE INNOVATION FOUNDATION (US) | 2018-03-08 | — | — | WO | disclosed |
| WO-2018045106-A1 | ANTI-FUNGAL TREATMENT | OHIO STATE INNOVATION FOUNDATION (US) | 2018-03-08 | — | — | WO | disclosed |
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365069-B2 | Pyrimidone derivatives | BEXEL PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-20040259891-A1 | Novel pyrimidon derivatives | ORCHID CHEMICAL & PHARMACEUTICALS LIMITED (IN) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259891-A1 | Novel pyrimidon derivatives | TYMS, TPMT, TYMP | RAB9A 2079/4885NPC1 1563/4885CDK5 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.