SCHEMBL4856255

SCHEMBL4856255

Cl[Sn](Cl)Cl.c1ccc(-c2ccc(-c3ccccc3)c3ccccc23)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.46
CYP2A6 P11509 1/20 0.46
ALDH1A1 P00352 5/20 0.42
BACE1 P56817 1/20 0.42
ALOX5 P09917 1/20 0.41
HPGD P15428 3/20 0.40
HSD17B10 Q99714 2/20 0.40
CTRC Q99895 2/20 0.40
MAPK1 P28482 2/20 0.40
BCL2L1 Q07817 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
MPI P34949 1/20 0.40
KMT2A Q03164 1/20 0.40
RAB9A P51151 1/20 0.39
RCE1 Q9Y256 1/20 0.39
BRD4 O60885 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3415539 0.88 ALDH1A1 (0.53) PARP1CYP2A6ALDH1A1BACE1ALOX5
SCHEMBL29728323 0.88 ALDH1A1 (0.53) PARP1CYP2A6ALDH1A1BACE1ALOX5
SCHEMBL2391683 0.79 ALDH1A1 (0.52) PARP1CYP2A6ALDH1A1BACE1HPGD
SCHEMBL29444814 0.79 PARP1 (0.43) PARP1CYP2A6ALDH1A1BACE1ALOX5
SCHEMBL21214803 0.79 CYP1A2 (0.67) CYP2A6ALDH1A1CTRCKDM4EMEN1
SCHEMBL2448362 0.79 PARP1 (0.43) PARP1CYP2A6ALDH1A1BACE1ALOX5
SCHEMBL30363359 0.79 CYP1A2 (0.67) CYP2A6ALDH1A1CTRCKDM4EMEN1
SCHEMBL14375337 0.79 CYP2A6 (0.65) PARP1CYP2A6ALDH1A1BACE1ALOX5
SCHEMBL17242010 0.79 PARP1 (0.43) PARP1CYP2A6ALDH1A1BACE1ALOX5
SCHEMBL27723481 0.78 ALDH1A1 (0.46) PARP1CYP2A6ALDH1A1BACE1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7393560-B2 Organo-metal compounds BRAGGONE OY (FI) 2008-07-01 US claimed
US-20060263621-A1 Novel organo-metal compounds BRAGGONE OY (FI) 2006-11-23 US claimed
US-7393560-B2 Organo-metal compounds BRAGGONE OY (FI) 2008-07-01 US disclosed
US-20060263621-A1 Novel organo-metal compounds BRAGGONE OY (FI) 2006-11-23 US disclosed