Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856539 | 0.89 | HTR7 (0.45) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4854299 | 0.86 | HTR7 (0.42) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4845580 | 0.86 | SLC6A9 (0.49) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4854610 | 0.85 | ALDH1A1 (0.49) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4856225 | 0.85 | HTR7 (0.62) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4847853 | 0.85 | SLC6A9 (0.50) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4853912 | 0.85 | HTR7 (0.54) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4846931 | 0.83 | HTR7 (0.46) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4853715 | 0.83 | ALDH1A1 (0.60) | HTR7ADRB2ADRB1ALDH1A1KDM4E | |
| SCHEMBL4852503 | 0.83 | ALDH1A1 (0.60) | HTR7ADRB2ADRB1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |