SCHEMBL4856433

SCHEMBL4856433

Nc1cccc(C(N)(c2ccccc2)c2cccc3ccccc23)c1N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 7/20 0.46
HSD17B10 Q99714 6/20 0.46
ALDH1A1 P00352 6/20 0.46
TSHR P16473 3/20 0.46
CYP3A4 P08684 2/20 0.46
KEAP1 Q14145 1/20 0.46
KCNN4 O15554 2/20 0.41
KIF11 P52732 1/20 0.38
HIF1A Q16665 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
KDM4E B2RXH2 4/20 0.34
GLA P06280 4/20 0.34
KMT2A Q03164 4/20 0.34
RAB9A P51151 4/20 0.34
POLB P06746 3/20 0.34
GAA P10253 3/20 0.34
LMNA P02545 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28381882 0.84 KCNN4 (0.53) HPGDHSD17B10ALDH1A1TSHRCYP3A4
SCHEMBL222895 0.84 KCNN4 (0.53) HPGDHSD17B10ALDH1A1TSHRCYP3A4
Hydrochloric Acid SCHEMBL27897779 0.83 KCNN4 (0.52) HPGDHSD17B10ALDH1A1TSHRCYP3A4
SCHEMBL3132847 0.75 KCNN4 (0.42) HPGDHSD17B10ALDH1A1TSHRCYP3A4
SCHEMBL10784751 0.71 CD44 (0.38) HPGDHSD17B10ALDH1A1TSHRCYP3A4
SCHEMBL572998 0.70 KCNN4 (0.59) HSD17B10ALDH1A1TSHRCYP3A4KCNN4
SCHEMBL2302240 0.70 CD44 (0.39) HPGDALDH1A1TSHRCYP3A4KCNN4
SCHEMBL7042389 0.70 KIF11 (0.42) HPGDHSD17B10ALDH1A1TSHRCYP3A4
SCHEMBL7584160 0.70 KCNN4 (0.52) ALDH1A1TSHRCYP3A4KCNN4KIF11
SCHEMBL5012463 0.69 ACP3 (0.46) HPGDHSD17B10ALDH1A1TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7338535-B2 Process for rapid dyeing and rapid decoloration of human keratin fibres with certain direct dyes L'OREAL S.A. (FR) 2008-03-04 US claimed
US-20040078906-A1 Process for rapid dyeing and rapid decoloration of human keratin fibres with certain direct dyes L'OREAL S.A. (FR) 2004-04-29 US claimed
US-7338535-B2 Process for rapid dyeing and rapid decoloration of human keratin fibres with certain direct dyes L'OREAL S.A. (FR) 2008-03-04 US disclosed
US-20040078906-A1 Process for rapid dyeing and rapid decoloration of human keratin fibres with certain direct dyes L'OREAL S.A. (FR) 2004-04-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040078906-A1 Process for rapid dyeing and rapid decoloration of human keratin fibres with certain direct dyes KRT18, CYBA, TYR HPGD 3525/4885HSD17B10 1495/4885ALDH1A1 2023/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.