SCHEMBL4858145

SCHEMBL4858145

O=C(O)c1ccc(Oc2ccc(-c3ccccc3)c(C(F)(F)F)c2C(F)(F)F)c(C(F)(F)F)c1C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 2/20 0.38
PTPN1 P18031 1/20 0.36
BACE1 P56817 1/20 0.36
FABP4 P15090 2/20 0.35
FABP3 P05413 1/20 0.35
FABP5 Q01469 1/20 0.35
HNF4A P41235 1/20 0.35
CYP2C8 P10632 1/20 0.35
SYK P43405 2/20 0.34
FOLH1 Q04609 2/20 0.34
ACLY P53396 1/20 0.34
HTT P42858 1/20 0.33
S1PR1 P21453 1/20 0.33
CLCN2 P51788 1/20 0.33
CDC25B P30305 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10626641 0.91 HNF4A (0.40) PTGDR2PTPN1BACE1FABP4FABP3
SCHEMBL4854755 0.90 FABP3 (0.38) PTGDR2PTPN1BACE1FABP4FABP3
SCHEMBL3193266 0.87 BACE1 (0.38) PTGDR2PTPN1BACE1FABP4FABP3
SCHEMBL3193336 0.86 HTT (0.45) HTTCDC25B
SCHEMBL3178432 0.85 HNF4A (0.38) PTGDR2PTPN1BACE1FABP4FABP3
SCHEMBL3755844 0.85 HTT (0.39) PTGDR2FABP4FABP5HTTCDC25B
SCHEMBL4858143 0.83 PTGDR2 (0.37) PTGDR2BACE1FABP4FOLH1S1PR1
SCHEMBL7189938 0.82 TTR (0.42)
SCHEMBL4858902 0.81 RXRA (0.43) FABP4HTT
SCHEMBL2524408 0.80 PTPN1 (0.46) PTPN1FABP4FABP3FABP5HNF4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7450803-B2 Optical waveguide HITACHI CHEMICAL COMPANY, LTD. (JP) 2008-11-11 US disclosed
US-20070086705-A1 Optical waveguide HITACHI CHEMICAL COMPANY, LTD. (JP) 2007-04-19 US disclosed
US-20030054184-A1 Optical element, method for the production thereof and optical module HITACHI CHEMICAL CO., LTD. (JP) 2003-03-20 US disclosed
EP-1232851-A2 Process for producing polyimide platy object Central Glass Company, Limited (JP) 2002-08-21 EP disclosed