Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698363 | 0.84 | HTT (0.48) | KCNH3HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL522061 | 0.77 | KCNH3 (0.68) | KCNH3HTTADRA2CLTA4HF2 | |
| SCHEMBL1043672 | 0.77 | SLC2A4 (0.51) | HTTGAAMAPTALDH1A1NPSR1 | |
| SCHEMBL3318487 | 0.76 | LTA4H (0.57) | GAAKDM4EMAPTALDH1A1PABPC1 | |
| SCHEMBL19241691 | 0.75 | F2 (0.56) | KCNH3HTTADRA2CGAAKDM4E | |
| SCHEMBL19242049 | 0.75 | KDM4E (0.61) | KCNH3HTTADRA2CGAAKDM4E | |
| SCHEMBL28330956 | 0.74 | F2 (0.49) | KCNH3HTTADRA2CGAAKDM4E | |
| SCHEMBL2526849 | 0.74 | RAD52 (0.45) | KCNH3ADRA2CKDM4EMAPTALDH1A1 | |
| SCHEMBL19242051 | 0.71 | F2 (0.61) | KCNH3HTTGAAKDM4EMAPT | |
| SCHEMBL1451843 | 0.71 | CYP11B1 (0.41) | MAPTLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465900-B1 | RHO-KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2008-05-14 | — | — | EP | claimed |