Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.68 |
| ▸ | LTA4H | P09960 | 1/20 | 0.63 |
| ▸ | F2 | P00734 | 3/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | GRK2 | P25098 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2126955 | 0.91 | F2 (0.70) | KCNH3LTA4HF2PRSS1ADRA2C | |
| Hydrochloric Acid SCHEMBL7422969 | 0.89 | F2 (0.68) | KCNH3LTA4HF2PRSS1ADRA2C | |
| Hydrochloric Acid SCHEMBL27679067 | 0.89 | F2 (0.68) | KCNH3LTA4HF2PRSS1ADRA2C | |
| SCHEMBL19242049 | 0.89 | KDM4E (0.61) | KCNH3F2PRSS1ADRA2CHTT | |
| SCHEMBL19241691 | 0.89 | F2 (0.56) | KCNH3LTA4HF2PRSS1ADRA2C | |
| SCHEMBL19242051 | 0.84 | F2 (0.61) | KCNH3LTA4HF2PRSS1HTT | |
| N-Benzylaniline SCHEMBL7840 | 0.84 | HTT (0.71) | KCNH3LTA4HHTTCA9MEN1 | |
| SCHEMBL22628164 | 0.84 | HTT (0.71) | KCNH3LTA4HHTTCA9MEN1 | |
| SCHEMBL2065031 | 0.84 | CYP1A2 (0.69) | LTA4HHTTCA9MEN1CYP1A2 | |
| SCHEMBL19241983 | 0.83 | KDM4E (0.56) | KCNH3F2ADRA2CHTTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470407-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2023081967-A1 | COMPOUNDS AND USES THEREFOR | THE UNIVERSITY OF WESTERN AUSTRALIA (AU) | 2023-05-19 | — | — | WO | disclosed |
| EP-3218350-B1 | PROCESS FOR FORMING AMINE BY DIRECT AMINATION REACTION | RHODIA OPERATIONS (FR) | 2022-01-05 | — | — | EP | disclosed |
| US-10953007-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2021-03-23 | — | — | US | disclosed |
| EP-3470407-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| US-10207980-B2 | Process for forming amine by direct amination reaction | RHODIA OPERATIONS (FR) | 2019-02-19 | — | — | US | disclosed |
| EP-2635572-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2018-10-17 | — | — | EP | disclosed |
| US-20180289704-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2018-10-11 | — | — | US | disclosed |
| US-10016418-B2 | Compounds useful as modulators of TRPM8 | Seaomyx, Inc. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170320811-A1 | PROCESS FOR FORMING AMINE BY DIRECT AMINATION REACTION | RHODIA OPERATIONS (FR) | 2017-11-09 | — | — | US | disclosed |
| WO-2002036119-A1 | Δ2,-1,2,3-TRIAZOLINE ANTICONVULSANTS AND THEIR ACTIVE METABOLITE ANALOGUES, THE AMINOALKYLPYRIDINES, ARE EXCITATORY AMINO ACID ANTAGONISTS AND ANTIISCHEMIC AGENTS, USEFUL IN THE TREATMENT OF CEREBRAL ISCHEMIA RESULTING FROM STROKE | K AND K BIOSCIENCES, INC. (US) | 2002-05-10 | — | — | WO | disclosed |
| EP-1087937-A1 | CYCLIC HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6207667-B1 | USEFUL FOR THE TREATMENT OF CELL-PROLIFERATIVE DISEASES SUCH AS ARTERIOSCLEROSIS, VASCULAR REOBSTRUCTION, CANCER AND GLOMERULOSCLEROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| US-6169088-B1 | FOR THE PREVENTION OR TREATMENT OF CELL-PROLIFERATIVE DISEASES SUCH AS ARTERIOSCLEROSIS, VASCULAR REOBSTRUCTION, CANCER AND GLOMERULOSCLEROSIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
| WO-1999065867-A1 | CYCLIC HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0882717-A1 | NITROGENOUS HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1998-12-09 | — | — | EP | disclosed |
| CN-1114311-A | Process for preparing 4-pyridylmethyl amine derivatives | DALIAN CHEMICAL PHYSICS INST (CN) | 1996-01-03 | — | — | CN | disclosed |
| EP-0189678-B1 | ELECTROCHEMICAL REDUCTIONS OF PYRIDINE CARBOXAMIDE BASES | REILLY INDUSTRIES, INC. (US) | 1991-11-06 | — | — | EP | disclosed |
| US-4695352-A | Electrochemical reduction of pyridine carboxamide bases | REILLY TAR & CHEMICAL CORPORATION (US) | 1987-09-22 | — | — | US | disclosed |
| EP-0189678-A1 | Electrochemical reductions of pyridine carboxamide bases | REILLY INDUSTRIES, INC. (US) | 1986-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10953007-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPM6 | KCNH3 153/4885LTA4H 1654/4885F2 3819/4885 |
| US-10016418-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPM6 | KCNH3 153/4885LTA4H 1654/4885F2 3819/4885 |
| US-10207980-B2 | Process for forming amine by direct amination reaction | ADH5, ADH1A, ADH1C | KCNH3 924/4885LTA4H 2635/4885F2 604/4885 |
| US-20180289704-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPM6 | KCNH3 153/4885LTA4H 1654/4885F2 3819/4885 |
| US-20170320811-A1 | PROCESS FOR FORMING AMINE BY DIRECT AMINATION REACTION | ADH5, ADH1A, ADH1C | KCNH3 924/4885LTA4H 2635/4885F2 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.