Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.35 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857411 | 1.00 | POLB (0.40) | POLBMAPTKMT2AMEN1S1PR1 | |
| SCHEMBL6185098 | 0.82 | POLB (0.40) | POLBMAPTKMT2AMEN1CGAS | |
| SCHEMBL19812532 | 0.82 | P2RY12 (0.40) | POLBMAPTPDGFRB | |
| SCHEMBL14525072 | 0.82 | SLC15A1 (0.44) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14268347 | 0.82 | SLC15A1 (0.44) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14268348 | 0.82 | SLC15A1 (0.44) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1927631 | 0.79 | ROCK2 (0.44) | ADORA1PDGFRBADORA2A | |
| SCHEMBL1927633 | 0.79 | ROCK2 (0.44) | ADORA1PDGFRBADORA2A | |
| SCHEMBL1927628 | 0.79 | ROCK2 (0.44) | ADORA1PDGFRBADORA2A | |
| Trifluoroacetic Acid SCHEMBL392970 | 0.79 | ROCK2 (0.40) | S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332517-B2 | Derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments | Société de Conseils de Recheres et d'Applications Scientifiques (SCRAS) (FR) | 2008-02-19 | — | — | US | disclosed |
| US-7199145-B2 | Derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D' 'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S) (FR) | 2007-04-03 | — | — | US | disclosed |
| US-20070021420-A1 | New derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments | SCRAS | 2007-01-25 | — | — | US | disclosed |
| EP-1246807-B1 | NOVEL HYDANTOIN, THIOHYDANTOIN, PYRIMIDINEDIONE AND THIOXOPYRIMIDINONE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | SOD CONSEILS RECH APPLIC (FR) | 2005-11-02 | — | — | EP | disclosed |
| US-6759415-B1 | Hydantoin thiohydantoin pyrimidinedione and thioxopyrimidinone derivatives preparation method and use as medicines | SOCIETE DE CONSEILS DE RECHERCHES ET D' APPLICATIONS SCIENTIFIQUES (FR) | 2004-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021420-A1 | New derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments | ADCYAP1R1, HPRT1, ALPI | POLB 3783/4885MAPT 4027/4885KMT2A 3752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.