Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 5/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 4/20 | 0.38 |
| ▸ | RARG | P13631 | 4/20 | 0.38 |
| ▸ | PYGL | P06737 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15235436 | 0.83 | PYGL (0.46) | NPC1RAB9AALDH1A1RXRAP2RX7 | |
| SCHEMBL485985 | 0.83 | PYGL (0.46) | NPC1RAB9AALDH1A1RXRAP2RX7 | |
| SCHEMBL878046 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9ALMNAPTK2B | |
| SCHEMBL1071564 | 0.72 | RXRA (0.46) | RXRARARBRARGCYP26A1RARA | |
| SCHEMBL803655 | 0.71 | RXRA (0.41) | TSHRALDH1A1MAPTRXRARARB | |
| SCHEMBL13189905 | 0.71 | KDM1A (0.46) | RXRARARBRARGCYP26A1RARA | |
| SCHEMBL27915456 | 0.65 | MAPT (0.51) | SMN1; SMN2NPC1RAB9ALMNAPTK2B | |
| SCHEMBL2815476 | 0.64 | PYGL (0.46) | NPC1RAB9AALDH1A1P2RX7SLC6A4 | |
| SCHEMBL17276229 | 0.64 | NPC1 (0.42) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL23362424 | 0.64 | CNR1 (0.41) | RXRARARBRARGTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |