Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.57 |
| ▸ | MPO | P05164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ACLY | P53396 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.47 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | LIPC | P11150 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10872978 | 0.82 | GRIK1 (0.48) | KDM4EALDH1A1HSD17B10GRIK1MEN1 | |
| SCHEMBL9119813 | 0.81 | CHRNA7 (0.53) | KDM4EALDH1A1HPGDHSD17B10MPO | |
| Hydrochloric Acid SCHEMBL9119630 | 0.80 | CHRNA7 (0.52) | KDM4EALDH1A1HPGDHSD17B10MPO | |
| Hydrochloric Acid SCHEMBL10720962 | 0.80 | GRIK1 (0.46) | KDM4EALDH1A1HSD17B10GRIK1MEN1 | |
| SCHEMBL11603313 | 0.78 | GRIK1 (0.62) | KDM4EALDH1A1GRIK1MEN1KMT2A | |
| SCHEMBL10385394 | 0.78 | MPO (0.81) | ALDH1A1GRIK1MPOMEN1KMT2A | |
| SCHEMBL29835007 | 0.78 | MPO (0.81) | ALDH1A1GRIK1MPOMEN1KMT2A | |
| SCHEMBL4854787 | 0.78 | MEN1 (0.47) | KDM4EALDH1A1HSD17B10GRIK1MEN1 | |
| SCHEMBL4848735 | 0.77 | AKR1C3 (0.64) | HPGDGRIK1MEN1KMT2AMAPT | |
| SCHEMBL3718012 | 0.76 | TAS2R14 (0.58) | KDM4EALDH1A1HPGDHSD17B10GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-B1 | 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS | ABBVIE INC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
| US-20040254159-A1 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254159-A1 | Heterocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | KDM4E 1309/4885ALDH1A1 2391/4885HPGD 1229/4885 |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | KDM4E 1406/4885ALDH1A1 3257/4885HPGD 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.