Sugi Predict

Sugi Predict / Compounds / SCHEMBL4860804

SCHEMBL4860804

SCHEMBL4860804

Cc1ccc(S(=O)(=O)N(CC(N)=O)c2ccc(Cl)cc2Cc2ccccc2Cl)cc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 4/20 0.43
▸ NFE2L2 Q16236 4/20 0.43
▸ ESR1 P03372 2/20 0.41
▸ PTGER1 P34995 1/20 0.41
▸ THRB P10828 3/20 0.41
▸ PKM P14618 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ TP53 P04637 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ HCRTR1 O43613 1/20 0.38
▸ HCRTR2 O43614 1/20 0.38
▸ PSEN1 P49768 2/20 0.38
▸ PSEN2 P49810 2/20 0.38
▸ APH1B Q8WW43 2/20 0.38
▸ NCSTN Q92542 2/20 0.38
▸ APH1A Q96BI3 2/20 0.38
▸ PSENEN Q9NZ42 2/20 0.38
▸ MCOLN3 Q8TDD5 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3253245 0.90 KEAP1 (0.51) KEAP1NFE2L2PTGER1THRBPKM
SCHEMBL3255469 0.89 KEAP1 (0.43) KEAP1NFE2L2PTGER1THRBPKM
SCHEMBL3247110 0.88 THRB (0.45) KEAP1NFE2L2PTGER1THRBPKM
SCHEMBL3251187 0.88 THRB (0.44) KEAP1NFE2L2PTGER1THRBPKM
SCHEMBL3249159 0.88 KEAP1 (0.48) KEAP1NFE2L2PTGER1THRBPKM
SCHEMBL3250637 0.87 FDFT1 (0.39) KEAP1NFE2L2PTGER1THRBHPGD
SCHEMBL3247753 0.87 PKM (0.57) KEAP1NFE2L2PTGER1PKMHPGD
SCHEMBL3244429 0.86 PTGER1 (0.42) KEAP1NFE2L2PTGER1THRBTP53
SCHEMBL3253720 0.85 KEAP1 (0.62) KEAP1NFE2L2
SCHEMBL4867374 0.85 KEAP1 (0.43) KEAP1NFE2L2PTGER1THRBPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7396958-B2 Sulphonamide derivatives, their preparation and their therapeutic application SANOFI AVENTIS (FR) 2008-07-08 — — US disclosed
US-7396958-B2 Sulphonamide derivatives, their preparation and their therapeutic application SANOFI AVENTIS (FR) 2008-07-08 — — US disclosed
US-7396958-B2 Sulphonamide derivatives, their preparation and their therapeutic application SANOFI AVENTIS (FR) 2008-07-08 — — US disclosed
US-20070185136-A1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI-AVENTIS (FR) 2007-08-09 — — US disclosed
US-20070185136-A1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI-AVENTIS (FR) 2007-08-09 — — US disclosed
US-20070185136-A1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI-AVENTIS (FR) 2007-08-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070185136-A1 SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION HCRTR2, GIPR, SSTR2 KEAP1 3317/4885NFE2L2 2700/4885ESR1 1962/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.