SCHEMBL4861330

SCHEMBL4861330

CC(C)(C)[SiH2]OC(C)(C)c1cnn(-c2ccc(NC(=O)O)cc2F)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPY2R P49146 2/20 0.35
SYK P43405 1/20 0.34
ABL1 P00519 4/20 0.34
BCR P11274 4/20 0.34
NPC1 O15118 4/20 0.34
RAB9A P51151 4/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MAPT P10636 3/20 0.32
CYP2C9 P11712 2/20 0.32
CYP2C19 P33261 2/20 0.32
PKM P14618 1/20 0.32
CYP3A4 P08684 2/20 0.32
CYP1A2 P05177 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
KDM4E B2RXH2 1/20 0.32
GCG P01275 1/20 0.32
GCGR P47871 1/20 0.32
NR1H4 Q96RI1 1/20 0.32
BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3750497 0.84 NPY2R (0.35) NPY2RSYKABL1BCRNPC1
SCHEMBL4861321 0.73 MALT1 (0.34) NPY2RSYKABL1BCRNPC1
SCHEMBL3759916 0.72 MALT1 (0.42) SYKABL1BCRNPC1RAB9A
SCHEMBL3752965 0.67 IMPDH2 (0.37) NPC1RAB9ASMN1; SMN2MAPTMEN1
SCHEMBL30767560 0.66 CYP1A2 (0.60) ABL1BCRSMN1; SMN2CYP2C9CYP2C19
SCHEMBL3753155 0.65 PSEN1 (0.37) NPY2RNPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL20282473 0.64 RXRA (0.43) CYP2C9CYP2C19CYP3A4CYP1A2
SCHEMBL480924 0.63 SYK (0.33) SYKSMN1; SMN2KDM4E
SCHEMBL29718834 0.62 IDH1 (0.44) ABL1BCRSMN1; SMN2MAPTKDM4E
SCHEMBL28280419 0.62 IDH1 (0.44) ABL1BCRSMN1; SMN2MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008143649-A2 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LIMITED (IN) 2008-11-27 WO disclosed