SCHEMBL4862706

SCHEMBL4862706

CCCc1c(-c2cc(Cl)c(O)c(Cl)c2)cc(Cl)c(O)c1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.43
HSD17B10 Q99714 4/20 0.36
TSHR P16473 3/20 0.36
HPGD P15428 3/20 0.36
MAPK1 P28482 2/20 0.36
HIF1A Q16665 4/20 0.36
CYP3A4 P08684 2/20 0.36
RECQL P46063 2/20 0.36
ESR1 P03372 2/20 0.36
THRB P10828 2/20 0.36
CYP1A2 P05177 2/20 0.36
ALOX15 P16050 2/20 0.36
ALOX12 P18054 2/20 0.36
CYP2C19 P33261 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36
USP2 O75604 1/20 0.36
EGFR P00533 1/20 0.36
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propane SCHEMBL29003929 0.74 TTR (0.78) TTRHSD17B10TSHRHPGDMAPK1
SCHEMBL10636096 0.73 HPGD (0.52) TTRHSD17B10TSHRHPGDMAPK1
SCHEMBL8057962 0.70 ESR2 (0.45) HSD17B10TSHRCYP3A4ESR1HSP90AA1
SCHEMBL445337 0.69 HSD17B10 (0.46) TTRHSD17B10TSHRHPGDMAPK1
SCHEMBL27440129 0.68 HPGD (0.43) TTRHSD17B10TSHRHPGDMAPK1
SCHEMBL8083612 0.68 GAA (0.34) HSD17B10TSHRHPGDMAPK1HIF1A
SCHEMBL6231470 0.67 HPGD (0.45) HSD17B10TSHRHPGDMAPK1HIF1A
Hydrochloric Acid SCHEMBL8075471 0.67 GAA (0.33) HSD17B10TSHRHPGDMAPK1HIF1A
SCHEMBL10636089 0.66 HPGD (0.44) TTRHSD17B10TSHRHPGDMAPK1
SCHEMBL5586618 0.66 HMGCR (0.39) HPGDMAPK1HIF1ARECQLTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6077928-A Bis(dialkylmaleimide) derivative and polyetherimide for optical communications formed therefrom SAMSUNG ELECTRONICS CO., LTD. (KR) 2000-06-20 US claimed
US-7329696-B2 Aqueous synthetic resin dispersion SANYO CHEMICAL INDUSTRIES, LTD. (JP) 2008-02-12 US disclosed
US-20050131081-A1 Aqueous synthethic resin dispersion SANYO CHEMICAL INDUSTRIES, LTD. (JP) 2005-06-16 US disclosed
US-6077928-A Bis(dialkylmaleimide) derivative and polyetherimide for optical communications formed therefrom SAMSUNG ELECTRONICS CO., LTD. (KR) 2000-06-20 US disclosed
US-6031061-A Bis (triaklyltrimellitic anhydride) derivative and polyesterimide for optical communications formed therefrom SAMSUNG ELECTRONICS CO., LTD. (KR) 2000-02-29 US disclosed
US-5227449-A Polydiphenylsiloxane-Carbonate Block Polymers XEROX CORPORATION (US) 1993-07-13 US disclosed
US-5166021-A Multilayer imaging member with charge generating and charge transport layers XEROX CORPORATION (US) 1992-11-24 US disclosed
US-5080987-A Photoconductive imaging members with polycarbonate binders XEROX CORPORATION (US) 1992-01-14 US disclosed
US-4921940-A Process for the purification of Ti containing polycarbonate with solvent, complexing agent and water XEROX CORPORATION (US) 1990-05-01 US disclosed
US-4722809-A BLEND WITH HAOLGENATED AROMATIC POLYCARBONATE THE DOW CHEMICAL COMPANY (US) 1988-02-02 US disclosed
US-4357385-A BLEND OF POLYESTER WITH ETHYLENE TEREPHTHALATE UNITS AND POLYETHYLENE NAPHTHALENEDICARBOXYLATE TEIJIN LIMITED (JP) 1982-11-02 US disclosed