SCHEMBL8057962

SCHEMBL8057962

CCCc1c(-c2ccc(O)c(Cl)c2)ccc(O)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 7/20 0.45
ESR1 P03372 7/20 0.45
ALOX5 P09917 2/20 0.42
CNR1 P21554 1/20 0.40
CNR2 P34972 1/20 0.40
HSD17B1 P14061 1/20 0.37
HSD17B2 P37059 1/20 0.37
TSHR P16473 1/20 0.37
HSD17B10 Q99714 1/20 0.37
AHR P35869 1/20 0.37
GABRA1 P14867 1/20 0.37
GABRB2 P47870 1/20 0.37
CYP17A1 P05093 1/20 0.36
CYP3A4 P08684 1/20 0.36
HSP90AA1 P07900 1/20 0.36
HSP90AB1 P08238 1/20 0.36
AR P10275 1/20 0.36
PTGS2 P35354 1/20 0.36
ADORA2A P29274 1/20 0.36
ADORA1 P30542 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28985928 0.75 CYP3A4 (0.50) CNR1CNR2TSHRHSD17B10CYP3A4
SCHEMBL10594577 0.75 ESR2 (0.53) ESR2ESR1HSD17B1HSD17B2TSHR
SCHEMBL3231646 0.71 ALOX5 (0.42) ESR2ESR1ALOX5CNR1CNR2
SCHEMBL4862706 0.70 TTR (0.43) ESR2ESR1CNR1CNR2TSHR
SCHEMBL9560533 0.70 ALOX5 (0.41) ESR2ESR1ALOX5CNR1CNR2
SCHEMBL28202577 0.70 ESR2 (0.77) ESR2ESR1ALOX5HSD17B1HSD17B2
SCHEMBL29911026 0.70 ESR2 (0.77) ESR2ESR1ALOX5HSD17B1HSD17B2
SCHEMBL278316 0.70 ESR2 (0.77) ESR2ESR1ALOX5HSD17B1HSD17B2
SCHEMBL631374 0.70 CNR1 (0.64) ALOX5CNR1CNR2TSHRHSD17B10
SCHEMBL7693914 0.70 CYP3A4 (0.48) ESR2ESR1CNR1CNR2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6077928-A Bis(dialkylmaleimide) derivative and polyetherimide for optical communications formed therefrom SAMSUNG ELECTRONICS CO., LTD. (KR) 2000-06-20 US claimed
US-6077928-A Bis(dialkylmaleimide) derivative and polyetherimide for optical communications formed therefrom SAMSUNG ELECTRONICS CO., LTD. (KR) 2000-06-20 US disclosed
US-6031061-A Bis (triaklyltrimellitic anhydride) derivative and polyesterimide for optical communications formed therefrom SAMSUNG ELECTRONICS CO., LTD. (KR) 2000-02-29 US disclosed
EP-0277804-B1 POLYCARBONATE FILMS EFFECTIVE AS OPTICAL PHASE RETARDERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-09-29 EP disclosed
US-5061042-A Phase retarder and liquid crystal display using the same SUMITOMO CHEMICAL CO., LTD. (JP) 1991-10-29 US disclosed
US-4722809-A BLEND WITH HAOLGENATED AROMATIC POLYCARBONATE THE DOW CHEMICAL COMPANY (US) 1988-02-02 US disclosed
US-4357385-A BLEND OF POLYESTER WITH ETHYLENE TEREPHTHALATE UNITS AND POLYETHYLENE NAPHTHALENEDICARBOXYLATE TEIJIN LIMITED (JP) 1982-11-02 US disclosed