Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP5 | Q96HI0 | 4/20 | 0.56 |
| ▸ | SENP2 | Q9HC62 | 4/20 | 0.56 |
| ▸ | SENP1 | Q9P0U3 | 4/20 | 0.56 |
| ▸ | SLC6A5 | Q9Y345 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485760 | 0.88 | NPC1 (0.46) | SENP5SENP2SENP1SLC6A5NPC1 | |
| Bicarbonate SCHEMBL485488 | 0.87 | SENP5 (0.45) | SENP5SENP2SENP1SLC6A5NPC1 | |
| SCHEMBL4634443 | 0.82 | SENP2 (0.62) | SENP5SENP2SENP1ALDH1A1 | |
| SCHEMBL485511 | 0.81 | CXCR2 (0.62) | SLC6A5MRGPRX4MEN1ALDH1A1KMT2A | |
| SCHEMBL485085 | 0.80 | SENP2 (0.58) | SENP5SENP2SENP1 | |
| SCHEMBL485699 | 0.79 | CXCR2 (0.62) | SLC6A5MRGPRX4MEN1ALDH1A1KMT2A | |
| SCHEMBL485458 | 0.79 | CXCR2 (0.64) | SENP5SENP2SENP1MRGPRX4 | |
| SCHEMBL485710 | 0.78 | MRGPRX4 (0.56) | SLC6A5MRGPRX4MEN1ALDH1A1KMT2A | |
| SCHEMBL485703 | 0.77 | MRGPRX4 (0.50) | SLC6A5MRGPRX4MEN1ALDH1A1KMT2A | |
| SCHEMBL4633569 | 0.77 | KMT2A (0.56) | SENP5SENP2SENP1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |