Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4863926 | 0.77 | KEAP1 (0.36) | KEAP1NFE2L2PDPK1PARP1KDM4E | |
| SCHEMBL10615477 | 0.74 | PARP1 (0.43) | KEAP1NFE2L2PDPK1PARP1KDM4E | |
| SCHEMBL4553803 | 0.73 | KDM4E (0.44) | KEAP1NFE2L2PARP1KDM4EALDH1A1 | |
| SCHEMBL7161047 | 0.70 | PARP1 (0.44) | KEAP1NFE2L2PDPK1PARP1KDM4E | |
| SCHEMBL652047 | 0.69 | ALDH1A1 (0.46) | KEAP1NFE2L2PDPK1PARP1KDM4E | |
| SCHEMBL7846834 | 0.69 | PARP1 (0.39) | KEAP1NFE2L2PDPK1PARP1KDM4E | |
| SCHEMBL28053292 | 0.68 | ALDH1A1 (0.56) | KEAP1NFE2L2PDPK1PARP1KDM4E | |
| SCHEMBL8813905 | 0.68 | ALDH1A1 (0.56) | KEAP1NFE2L2PDPK1PARP1KDM4E | |
| SCHEMBL967996 | 0.68 | ALDH1A1 (0.56) | KEAP1NFE2L2PDPK1PARP1KDM4E | |
| SCHEMBL2685882 | 0.67 | ALDH1A1 (0.45) | KEAP1NFE2L2PDPK1PARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080226550-A1 | SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TUMORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-09-18 | — | — | US | disclosed |
| US-7321027-B2 | Small technetium-99m and rhenium labeled agents and methods for imaging tumors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1276718-B1 | SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TUMORS | HARVARD COLLEGE (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20040097735-A1 | Small technetium-99m and rhenium labeled agents and methods for imaging tumors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2004-05-20 | — | — | US | disclosed |
| EP-1276718-A2 | SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TUMORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001083436-A2 | SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TUMORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080226550-A1 | SMALL TECHNETIUM-99M AND RHENIUM LABELED AGENTS AND METHODS FOR IMAGING TUMORS | VHL, MEN1, NRAS | KEAP1 1031/4885NFE2L2 1896/4885PDPK1 4190/4885 |
| US-20040097735-A1 | Small technetium-99m and rhenium labeled agents and methods for imaging tumors | VHL, MEN1, NRAS | KEAP1 1031/4885NFE2L2 1896/4885PDPK1 4190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.