Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12869168 | 0.79 | LMNA (0.83) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL486694 | 0.78 | LMNA (0.74) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL486154 | 0.78 | NPSR1 (0.56) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL13284544 | 0.78 | LMNA (0.54) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL486153 | 0.76 | NPSR1 (0.84) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL9893121 | 0.76 | GAA (0.57) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL486324 | 0.75 | LMNA (1.00) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL14087599 | 0.74 | NPSR1 (0.37) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL486054 | 0.74 | NPSR1 (0.97) | LMNANPSR1ALDH1A1GAAKDM4E | |
| SCHEMBL486082 | 0.74 | NPSR1 (0.90) | LMNANPSR1ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144769-A1 | COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2022-05-12 | — | — | US | disclosed |
| EP-2145884-B1 | INDOLEDIONE DERIVATIVE | MSD KK (JP) | 2014-08-06 | — | — | EP | disclosed |
| EP-2188269-B1 | ARYL SULFONAMIDES WITH ANALGESIC ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2014-05-07 | — | — | EP | disclosed |
| EP-2188269-B1 | ARYL SULFONAMIDES WITH ANALGESIC ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2014-05-07 | — | — | EP | disclosed |
| US-8394805-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-12 | — | — | US | disclosed |
| US-8394805-B2 | Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-03-12 | — | — | US | disclosed |
| US-8106086-B2 | Indoledione derivative | MSD K.K. (JP) | 2012-01-31 | — | — | US | disclosed |
| US-20110098282-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-28 | — | — | US | disclosed |
| US-20110098282-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-28 | — | — | US | disclosed |
| EP-2188269-A1 | NEW COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2010-05-26 | — | — | EP | disclosed |
| US-20100056597-A1 | INDOLEDIONE DERIVATIVE | MSD K.K. (JP) | 2010-03-04 | — | — | US | disclosed |
| EP-2145884-A1 | INDOLEDIONE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-01-20 | — | — | EP | disclosed |
| WO-2009021944-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-19 | — | — | WO | disclosed |
| WO-2009021944-A1 | NEW COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-19 | — | — | WO | disclosed |
| US-6162918-A | Xanthene and acridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2000-12-19 | — | — | US | disclosed |
| US-5969139-A | INHIBITORS OF HERPES SIMPLEX VIRUS THYMIDINE KINASE | HOFFMANN-LA ROCHE INC. (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0823426-A1 | Xanthene and acridine derivatives and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-02-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056597-A1 | INDOLEDIONE DERIVATIVE | LIPE, IDO1, ADRA1A | LMNA 1165/4885NPSR1 761/4885ALDH1A1 303/4885 |
| US-20220144769-A1 | COMPOUND | CBR3, SFXN3, CBR1 | LMNA 4541/4885NPSR1 1073/4885ALDH1A1 928/4885 |
| US-20110098282-A1 | NEW COMPOUNDS | BRDT, AURKAIP1, ABCG2 | LMNA 3622/4885NPSR1 2321/4885ALDH1A1 2750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.