Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27888985 | 0.81 | MAPT (0.51) | CYP1A2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6129263 | 0.81 | AKR1C2 (0.61) | CYP1A2MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL4864056 | 0.80 | TUBB1 (0.49) | CYP1A1CYP1A2CYP1B1MEN1KMT2A | |
| SCHEMBL11755939 | 0.78 | CYP1A1 (0.46) | CYP1A1CYP1A2CYP1B1MEN1KMT2A | |
| SCHEMBL2446110 | 0.76 | MAPT (0.66) | CYP1A2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL30023422 | 0.76 | MAPT (0.66) | CYP1A2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8526794 | 0.76 | PKM (0.53) | CYP1A2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL27660465 | 0.74 | ALDH1A1 (0.48) | CYP1A2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL31436378 | 0.73 | CYP1A1 (0.72) | CYP1A1CYP1A2CYP1B1MEN1KMT2A | |
| SCHEMBL14315253 | 0.73 | CYP1A1 (0.72) | CYP1A1CYP1A2CYP1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065213-A1 | Combretastatin a-4 derivatives having antineoplastic activity | LAWRENCE NICHOLAS JAMES (GB) | 2005-03-24 | — | — | US | disclosed |
| EP-1444190-A1 | COMBRETASTATIN A-4 DERIVATIVES HAVING ANTINEOPLASTIC ACTIVITY | Cancer Research Technology Limited (GB) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040077-A1 | COMBRETASTATIN A-4 DERIVATIVES HAVING ANTINEOPLASTIC ACTIVITY | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065213-A1 | Combretastatin a-4 derivatives having antineoplastic activity | AURKA, AURKB, HDAC4 | CYP1A1 2327/4885CYP1A2 2218/4885CYP1B1 1238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.