Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL486429 | 1.00 | MEN1 (0.40) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486776 | 0.88 | AMY1A (0.43) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486775 | 0.88 | AMY1A (0.43) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486711 | 0.87 | MAPT (0.43) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486539 | 0.87 | KMT2A (0.39) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486538 | 0.87 | KMT2A (0.39) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486091 | 0.86 | MEN1 (0.42) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486092 | 0.86 | MEN1 (0.42) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486344 | 0.86 | MAPT (0.42) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL486345 | 0.86 | MAPT (0.42) | MEN1KMT2AMAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145884-B1 | INDOLEDIONE DERIVATIVE | MSD KK (JP) | 2014-08-06 | — | — | EP | disclosed |
| US-8106086-B2 | Indoledione derivative | MSD K.K. (JP) | 2012-01-31 | — | — | US | disclosed |
| US-20100056597-A1 | INDOLEDIONE DERIVATIVE | MSD K.K. (JP) | 2010-03-04 | — | — | US | disclosed |
| EP-2145884-A1 | INDOLEDIONE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056597-A1 | INDOLEDIONE DERIVATIVE | LIPE, IDO1, ADRA1A | MEN1 2086/4885KMT2A 776/4885MAPT 2831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.