Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | GALR1 | P47211 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3097478 | 0.91 | KDM1A (0.41) | TLR9GALR2GALR1KDM1ALMNA | |
| SCHEMBL3108841 | 0.89 | GALR2 (0.44) | TLR9GALR2GALR1KDM1ALMNA | |
| SCHEMBL3108033 | 0.83 | AOC3 (0.38) | TLR9GALR2GALR1KDM1ALMNA | |
| SCHEMBL3095300 | 0.81 | AXL (0.53) | — | |
| SCHEMBL3106580 | 0.79 | MET (0.45) | TLR9GALR2GALR1LMNAMAPT | |
| SCHEMBL3106664 | 0.79 | ALDH1A1 (0.45) | GALR2GALR1KDM1AGPR119ALDH1A1 | |
| SCHEMBL3099944 | 0.79 | AXL (0.51) | — | |
| SCHEMBL3101367 | 0.79 | ALDH1A1 (0.41) | KDM1AMAPTALDH1A1 | |
| SCHEMBL1945933 | 0.78 | KDM1A (0.39) | KDM1AGPR119SLC2A1ALDH1A1 | |
| SCHEMBL1944319 | 0.78 | GPR119 (0.41) | KDM1AGPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001880-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | Array Biopharma, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007103308-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-09-13 | — | — | WO | disclosed |