Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.79 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373208 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL5359262 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL14759162 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL8350565 | 0.77 | KDM4E (0.71) | KDM4EALDH1A1MAPK14RAB9AHPGD | |
| SCHEMBL12797503 | 0.76 | KDM4E (0.70) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL19182675 | 0.76 | MET (0.59) | KDM4EALDH1A1METMAPK14RAB9A | |
| SCHEMBL19292935 | 0.76 | ALDH1A1 (0.54) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL14759243 | 0.76 | KDM4E (0.69) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL7980785 | 0.75 | KDM4E (0.62) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL24273206 | 0.74 | KDM4E (0.67) | KDM4EALDH1A1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |
| EP-1601672-A1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | Pfizer Products Inc. (US) | 2005-12-07 | — | — | EP | disclosed |
| US-20050075365-A1 | Novel triazolo-pyridines as anti-inflammatory compounds | PFIZER, INC. (US) | 2005-04-07 | — | — | US | disclosed |
| WO-2004072072-A1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075365-A1 | Novel triazolo-pyridines as anti-inflammatory compounds | MAPK6, IL6, GRK6 | KDM4E 4323/4885ALDH1A1 3595/4885MET 1127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.