Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 4/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175267 | 0.87 | KMO (0.46) | KCNQ3KCNQ2PTGS2DHODHSLC6A7 | |
| SCHEMBL14710420 | 0.83 | PTGS2 (0.41) | KCNQ3KCNQ2PTGS2RORCTRPV1 | |
| SCHEMBL29939968 | 0.80 | HTR6 (0.43) | KCNQ3KCNQ2JAK2PTGS2RORC | |
| SCHEMBL30627413 | 0.77 | ELANE (0.42) | KCNQ3KCNQ2PPARGRORC | |
| SCHEMBL23023568 | 0.75 | PTGS2 (0.41) | KCNQ3KCNQ2PTGS2RORC | |
| SCHEMBL15210509 | 0.75 | POLB (0.48) | KCNQ3KCNQ2PTGS2 | |
| SCHEMBL27230023 | 0.75 | PIK3CD (0.46) | KCNQ3KCNQ2JAK2 | |
| SCHEMBL29703839 | 0.74 | DHODH (0.42) | PTGS2DHODH | |
| SCHEMBL23013809 | 0.74 | DHODH (0.42) | PTGS2DHODH | |
| SCHEMBL30028953 | 0.74 | KCNQ3 (0.38) | KCNQ3KCNQ2PTGS2PPARGRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008530042-A | — | — | 2008-08-07 | — | — | JP | claimed |
| EP-1851225-A1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006084634-A1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-17 | — | — | WO | claimed |