Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872959 | 0.94 | TGFBR1 (0.48) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL4862130 | 0.81 | TGFBR1 (0.53) | KDM4ETGFBR1MAPK14L3MBTL1THRB | |
| SCHEMBL4873701 | 0.80 | AKT1 (0.46) | TGFBR1MAPK14THRBGSK3BTGFBR2 | |
| SCHEMBL4872814 | 0.79 | MAPK14 (0.45) | TGFBR1MAPK14THRBGSK3BTGFBR2 | |
| SCHEMBL4865628 | 0.78 | MAPK14 (0.44) | NPC1RAB9AKDM4EPKMALDH1A1 | |
| SCHEMBL4868119 | 0.78 | MAPK14 (0.60) | TGFBR1MAPK14THRBGSK3BTGFBR2 | |
| SCHEMBL4872159 | 0.78 | TGFBR1 (0.55) | MAPTALDH1A1TGFBR1MAPK14THRB | |
| SCHEMBL4869284 | 0.78 | MAPT (0.43) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL4867464 | 0.78 | MAPK14 (0.46) | TGFBR1MAPK14THRBGSK3BTGFBR2 | |
| SCHEMBL4873746 | 0.77 | TGFBR1 (0.47) | TGFBR1MAPK14THRBGSK3BTGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |