Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4867435 | 0.94 | NPC1 (0.43) | TGFBR1MAPK14RIPK2ACVR1BTDP1 | |
| SCHEMBL4862130 | 0.81 | TGFBR1 (0.53) | TGFBR1MAPK14MEN1KMT2AKDM4E | |
| SCHEMBL4873701 | 0.80 | AKT1 (0.46) | TGFBR1MAPK14MAPK1 | |
| SCHEMBL4872814 | 0.79 | MAPK14 (0.45) | TGFBR1MAPK14MAPK1 | |
| SCHEMBL4868119 | 0.78 | MAPK14 (0.60) | TGFBR1MAPK14 | |
| SCHEMBL4872159 | 0.78 | TGFBR1 (0.55) | TGFBR1MAPK14ALDH1A1MAPTHPGD | |
| SCHEMBL4865628 | 0.78 | MAPK14 (0.44) | TGFBR1MAPK14NPC1KDM4EALDH1A1 | |
| SCHEMBL4869284 | 0.78 | MAPT (0.43) | TGFBR1MAPK14NPC1SMN1; SMN2KDM4E | |
| SCHEMBL4867464 | 0.78 | MAPK14 (0.46) | TGFBR1MAPK14MAPK1 | |
| SCHEMBL4873746 | 0.77 | TGFBR1 (0.47) | TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |