Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.32 |
| ▸ | THRB | P10828 | 5/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.31 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2044548 | 0.78 | METAP2 (0.33) | — | |
| SCHEMBL6808735 | 0.76 | TGFBR1 (0.33) | TGFBR1TGFBR2 | |
| SCHEMBL6601320 | 0.74 | CYP2D6 (0.31) | TGFBR1TGFBR2 | |
| SCHEMBL5139233 | 0.74 | — | — | |
| SCHEMBL6917532 | 0.74 | TGFBR1 (0.31) | TGFBR1TGFBR2 | |
| SCHEMBL14576882 | 0.72 | TGFBR1 (0.48) | TGFBR1 | |
| SCHEMBL4873701 | 0.70 | AKT1 (0.46) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL3441964 | 0.69 | SLC2A1 (0.40) | — | |
| SCHEMBL4862130 | 0.68 | TGFBR1 (0.53) | TGFBR1THRBMAPK14TGFBR2 | |
| SCHEMBL6390141 | 0.67 | RAB9A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |