Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 12/20 | 0.37 |
| ▸ | HTR2A | P28223 | 8/20 | 0.37 |
| ▸ | HTR2C | P28335 | 8/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4871924 | 0.81 | CHRM2 (0.41) | DRD3KCNH2HRH1CHRM2CHRM4 | |
| SCHEMBL14684249 | 0.74 | RAB9A (0.56) | NPC1MAPK1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2309798 | 0.72 | NPC1 (0.61) | DRD3KCNH2NPC1MAPK1RAB9A | |
| SCHEMBL4876481 | 0.69 | ESR2 (0.43) | DRD3KCNH2HRH1MAPT | |
| SCHEMBL16716025 | 0.66 | RAB9A (0.51) | NPC1MAPK1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL14274194 | 0.65 | RAB9A (0.46) | DRD3KCNH2NPC1MAPK1RAB9A | |
| SCHEMBL4877007 | 0.63 | HTR2B (0.43) | DRD3KCNH2HRH1CHRM2CHRM4 | |
| SCHEMBL24199111 | 0.63 | NPC1 (0.43) | NPC1MAPK1RAB9ASMN1; SMN2GAA | |
| SCHEMBL19114655 | 0.63 | SMN1; SMN2 (0.52) | DRD3KCNH2HRH1NPC1MAPK1 | |
| SCHEMBL14684234 | 0.63 | RAB9A (0.43) | NPC1MAPK1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269195-A1 | Compounds Having Affinity For the Dopamine D3 Receptor and Uses Thereof in Medicine | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | US | disclosed |
| US-20080269195-A1 | Compounds Having Affinity For the Dopamine D3 Receptor and Uses Thereof in Medicine | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | US | disclosed |
| US-20080269195-A1 | Compounds Having Affinity For the Dopamine D3 Receptor and Uses Thereof in Medicine | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | US | disclosed |
| EP-1773844-A1 | COMPOUNDS HAVING AFFINITY FOR THE DOPAMINE D3 RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002928-A1 | COMPOUNDS HAVING AFFINITY FOR THE DOPAMINE D3 RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269195-A1 | Compounds Having Affinity For the Dopamine D3 Receptor and Uses Thereof in Medicine | DRD3, SLC6A3, DRD2 | DRD3 1/4885KCNH2 686/4885HRH1 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.