Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865015 | 0.89 | TGFBR1 (0.57) | TGFBR1MAPK14PTGS2PTGS1 | |
| SCHEMBL4857759 | 0.86 | PTGS2 (0.44) | TGFBR1MAPK14PTGS2PTGS1PRKD3 | |
| SCHEMBL4865060 | 0.83 | TGFBR1 (0.54) | TGFBR1MAPK14PTGS2PTGS1 | |
| SCHEMBL4868724 | 0.83 | TGFBR1 (0.42) | TGFBR1MAPK14PTGS2PTGS1PRKD3 | |
| SCHEMBL3092632 | 0.81 | PTGS2 (0.42) | TGFBR1MAPK14PTGS2PTGS1PRKD3 | |
| SCHEMBL4857758 | 0.80 | TGFBR1 (0.56) | TGFBR1MAPK14MTOR | |
| SCHEMBL4865043 | 0.80 | TGFBR1 (0.59) | TGFBR1MAPK14MTOR | |
| SCHEMBL4878226 | 0.80 | TGFBR1 (0.59) | TGFBR1MAPK14MTOR | |
| SCHEMBL3085480 | 0.80 | PTGS2 (0.44) | TGFBR1PTGS2PTGS1PRKD3MAP4K4 | |
| SCHEMBL4867900 | 0.77 | TGFBR1 (0.56) | TGFBR1MAPK14MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275235-A1 | NOVEL FUSED HETEROAROMATIC COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-7417041-B2 | Imidazopyrimidines as transforming growth factor (TGF) inhibitors | PFIZER INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-20040176390-A1 | Novel fused heteroaromatic compounds as transforming growth factor (TGF) inhibitors | PFIZER INC | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275235-A1 | NOVEL FUSED HETEROAROMATIC COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | TGFBR1, SMAD3, SMAD2 | TGFBR1 1/4885MAPK14 1127/4885MTOR 162/4885 |
| US-20040176390-A1 | Novel fused heteroaromatic compounds as transforming growth factor (TGF) inhibitors | SMAD3, TGFBR1, SMAD2 | TGFBR1 2/4885MAPK14 1223/4885MTOR 201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.