Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12330476 | 0.98 | ESR1 (0.42) | ESR1CYP19A1ESR2MTNR1AMTNR1B | |
| SCHEMBL9154102 | 0.87 | CYP2D6 (0.53) | ESR1CYP19A1ESR2CYP2D6ADRA1A | |
| SCHEMBL12330475 | 0.85 | KMT2A (0.50) | ESR1CYP19A1ESR2MTNR1AMTNR1B | |
| SCHEMBL23153214 | 0.84 | PTGS2 (0.44) | ADRA1ATAAR1 | |
| SCHEMBL13937 | 0.83 | TAAR1 (0.53) | ADRA1ATAAR1CYP1A2MEN1KMT2A | |
| SCHEMBL580782 | 0.81 | ADRA1A (0.60) | MTNR1AMTNR1BADRA1ATAAR1HSD17B10 | |
| SCHEMBL581189 | 0.81 | ADRA1A (0.60) | MTNR1AMTNR1BADRA1ATAAR1HSD17B10 | |
| SCHEMBL14255244 | 0.81 | HDAC1 (0.44) | ESR1CYP19A1ESR2MTNR1AMTNR1B | |
| SCHEMBL580778 | 0.81 | ADRA1A (0.60) | MTNR1AMTNR1BADRA1ATAAR1HSD17B10 | |
| SCHEMBL581519 | 0.81 | ADRA1A (0.60) | MTNR1AMTNR1BADRA1ATAAR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345035-B2 | Treatment of osteoporosis and autoimmune disease with astrogorgiadiol | UNIVERSITY OF DELAWARE (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345035-B2 | Treatment of osteoporosis and autoimmune disease with astrogorgiadiol | UNIVERSITY OF DELAWARE (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345035-B2 | Treatment of osteoporosis and autoimmune disease with astrogorgiadiol | UNIVERSITY OF DELAWARE (US) | 2008-03-18 | — | — | US | disclosed |
| US-20040242677-A1 | Treatment of osteoporosis and autoimmune disease with astrogorgiadiol | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242677-A1 | Treatment of osteoporosis and autoimmune disease with astrogorgiadiol | SOST, PTH1R, CALCR | ESR1 237/4885CYP19A1 434/4885ESR2 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.