Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.52 |
| ▸ | THRB | P10828 | 7/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868119 | 0.80 | MAPK14 (0.60) | TGFBR1THRBMAPK14PTGS2EGFR | |
| SCHEMBL4868672 | 0.78 | TGFBR1 (0.49) | TGFBR1THRBMAPK14PTGS2 | |
| SCHEMBL4874607 | 0.72 | TGFBR1 (0.52) | TGFBR1THRBMAPK14EGFRRAF1 | |
| SCHEMBL4867464 | 0.71 | MAPK14 (0.46) | TGFBR1THRBMAPK14EGFRRAF1 | |
| SCHEMBL4873313 | 0.71 | TGFBR1 (0.51) | TGFBR1THRBMAPK14 | |
| SCHEMBL414625 | 0.70 | TGFBR1 (0.49) | TGFBR1THRBMAPK14 | |
| SCHEMBL4862130 | 0.69 | TGFBR1 (0.53) | TGFBR1THRBMAPK14EGFRRAF1 | |
| SCHEMBL4869716 | 0.69 | PTGS2 (0.53) | TGFBR1THRBMAPK14PTGS2 | |
| SCHEMBL4873701 | 0.69 | AKT1 (0.46) | TGFBR1THRBMAPK14EGFRRAF1 | |
| SCHEMBL2757252 | 0.69 | CCR1 (0.60) | TGFBR1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |