Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865446 | 0.81 | TGFBR1 (0.53) | TGFBR1THRBMAPK14KDM4EALDH1A1 | |
| SCHEMBL4869260 | 0.78 | TGFBR1 (0.52) | TGFBR1THRBMAPK14PTGS2 | |
| SCHEMBL5235429 | 0.73 | ALDH1A1 (0.44) | TGFBR1KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL4868119 | 0.72 | MAPK14 (0.60) | TGFBR1THRBMAPK14PTGS2 | |
| SCHEMBL5237121 | 0.71 | TGFBR1 (0.41) | TGFBR1THRBKDM4EALDH1A1HPGD | |
| SCHEMBL4873313 | 0.71 | TGFBR1 (0.51) | TGFBR1THRBMAPK14CYP1A2CYP2C19 | |
| SCHEMBL4865701 | 0.70 | EGFR (0.55) | TGFBR1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3826301 | 0.68 | GAA (0.53) | MAPK14KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL414625 | 0.68 | TGFBR1 (0.49) | TGFBR1THRBMAPK14 | |
| SCHEMBL8364027 | 0.67 | TSHR (0.52) | KDM4EALDH1A1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |