Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4866183 | 0.86 | PGR (0.31) | — | |
| SCHEMBL4875009 | 0.86 | PGR (0.31) | — | |
| SCHEMBL4556512 | 0.85 | ROCK2 (0.34) | ROCK2AKT1ROCK1ERN1 | |
| SCHEMBL4556510 | 0.81 | ROCK2 (0.40) | ROCK2AKT1ROCK1 | |
| SCHEMBL4554649 | 0.79 | ROCK2 (0.34) | ROCK2AKT1ROCK1 | |
| SCHEMBL4556418 | 0.78 | ROCK2 (0.34) | ROCK2AKT1 | |
| SCHEMBL14146724 | 0.78 | ROCK2 (0.34) | ROCK2AKT1 | |
| SCHEMBL4442827 | 0.70 | CACNA1C (0.32) | — | |
| SCHEMBL4886889 | 0.69 | PGR (0.33) | — | |
| SCHEMBL4892910 | 0.69 | PGR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432276-B2 | ABCA1 elevating compounds | CV THERAPEUTICS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-20070191379-A1 | ABCA1 elevating compounds | CV THERAPEUTICS, INC. | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191379-A1 | ABCA1 elevating compounds | ABCD3, ABCB4, CETP | ROCK2 2907/4885AKT1 1281/4885ROCK1 2970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.