Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705032 | 0.84 | ALDH1A1 (0.49) | ALDH1A1LMNATP53SMN1; SMN2MLYCD | |
| SCHEMBL8426915 | 0.84 | ALDH1A1 (0.49) | ALDH1A1LMNATP53SMN1; SMN2GSK3B | |
| SCHEMBL22311444 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNATP53SMN1; SMN2GSK3B | |
| SCHEMBL22289629 | 0.83 | ALDH1A1 (0.51) | ALDH1A1LMNATP53SMN1; SMN2GPBAR1 | |
| SCHEMBL5103764 | 0.83 | ALDH1A1 (0.47) | ALDH1A1LMNATP53SMN1; SMN2MLYCD | |
| SCHEMBL5107126 | 0.82 | ALDH1A1 (0.69) | ALDH1A1LMNATP53SMN1; SMN2GSK3B | |
| SCHEMBL11383766 | 0.81 | LMNA (0.50) | ALDH1A1LMNATP53SMN1; SMN2GPBAR1 | |
| SCHEMBL11384569 | 0.81 | ALDH1A1 (0.40) | ALDH1A1LMNATP53SMN1; SMN2GSK3B | |
| SCHEMBL4869949 | 0.80 | GSK3B (0.49) | ALDH1A1LMNATP53SMN1; SMN2GSK3B | |
| SCHEMBL8430703 | 0.79 | MLYCD (0.49) | ALDH1A1LMNATP53SMN1; SMN2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442693-B2 | Diazepine compounds as ligands of the melanocortin 1 and/or 4 receptors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-28 | — | — | US | disclosed |
| US-20070270411-A1 | Novel Diazepine Compounds as Ligands of the Melanocortin 1 and/or 4 Receptors | SMITHKLINE BEECHAM CORPORATION | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270411-A1 | Novel Diazepine Compounds as Ligands of the Melanocortin 1 and/or 4 Receptors | MC4R, MC3R, MC5R | ALDH1A1 2986/4885LMNA 3785/4885TP53 4881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.