Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 3/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4871304 | 0.98 | MAPK14 (0.46) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| SCHEMBL4862089 | 0.97 | MAPK14 (0.43) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| SCHEMBL4868836 | 0.95 | MAPK14 (0.42) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4867644 | 0.95 | MAPK14 (0.42) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| SCHEMBL4868850 | 0.95 | MAPK14 (0.42) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| SCHEMBL4866517 | 0.95 | MAPK14 (0.42) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4862098 | 0.93 | MAPK14 (0.41) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4870219 | 0.93 | MAPK14 (0.41) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4862108 | 0.93 | MAPK14 (0.41) | MAPK14CHRNB2CHRNA4MAPTSMN1; SMN2 | |
| SCHEMBL4866507 | 0.82 | CYP2A6 (0.50) | CHRNB2CHRNA4MAPTSMN1; SMN2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384961-B2 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | GRUENENTHAL GMBH (DE) | 2008-06-10 | — | — | US | claimed |
| EP-1572653-B1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | GRUENENTHAL GMBH (DE) | 2007-11-21 | — | — | EP | claimed |
| JP-2006523182-A | — | — | 2006-10-12 | — | — | JP | claimed |
| US-20060025456-A1 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | GRUENENTHAL GMBH (DE) | 2006-02-02 | — | — | US | claimed |
| EP-1572653-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2005-09-14 | — | — | EP | claimed |
| WO-2004063161-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2004-07-29 | — | — | WO | claimed |
| US-7384961-B2 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | GRUENENTHAL GMBH (DE) | 2008-06-10 | — | — | US | disclosed |
| EP-1572653-B1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | GRUENENTHAL GMBH (DE) | 2007-11-21 | — | — | EP | disclosed |
| US-20060025456-A1 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | GRUENENTHAL GMBH (DE) | 2006-02-02 | — | — | US | disclosed |
| EP-1572653-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004063161-A1 | SATURATED AND UNSATURATED HETEROARYLCYCLOALKYLMETHYL AMINES AS ANTI-DEPRESSANTS | Grünenthal GmbH (DE) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025456-A1 | Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants | OPRK1, OPRM1, HTR1A | MAPK14 1519/4885CHRNB2 256/4885CHRNA4 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.