SCHEMBL487121

SCHEMBL487121

Cc1ccc2sc3cc(C(=O)Cl)ccc3c(=O)c2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
KDM4E B2RXH2 4/20 0.47
POLB P06746 3/20 0.47
HPGD P15428 2/20 0.47
BCL2L1 Q07817 1/20 0.41
MCL1 Q07820 1/20 0.41
MAPT P10636 9/20 0.38
NPC1 O15118 4/20 0.38
RAB9A P51151 4/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
GAA P10253 3/20 0.36
LMNA P02545 2/20 0.36
ESR1 P03372 1/20 0.36
HCRTR1 O43613 2/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
NFKB1 P19838 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11244498 0.90 BCL2L1 (0.44) ALDH1A1KDM4EPOLBHPGDBCL2L1
SCHEMBL28458734 0.90 KDM4E (0.46) ALDH1A1KDM4EPOLBHPGDMCL1
SCHEMBL473687 0.87 BCL2L1 (0.46) ALDH1A1KDM4EPOLBHPGDBCL2L1
SCHEMBL28460242 0.86 KDM4E (0.40) ALDH1A1KDM4EHPGDBCL2L1MCL1
Hydrochloric Acid SCHEMBL487123 0.86 ALDH1A1 (0.44) ALDH1A1KDM4EPOLBHPGDBCL2L1
SCHEMBL31314634 0.83 CMA1 (0.48) ALDH1A1KDM4EPOLBHPGDMAPT
SCHEMBL4541593 0.83 CMA1 (0.48) ALDH1A1KDM4EPOLBHPGDMAPT
SCHEMBL14985633 0.83 ALDH1A1 (0.50) ALDH1A1KDM4EPOLBHPGDBCL2L1
SCHEMBL28458672 0.83 KDM4E (0.47) ALDH1A1KDM4EPOLBHPGDMAPT
SCHEMBL9329684 0.82 KDM4E (0.53) ALDH1A1KDM4EPOLBHPGDMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2638027-B1 LOW-EXTRACTABLE THIOXANTHONES IGM RESINS ITALIA SRL (IT) 2016-07-13 EP disclosed
US-8933142-B2 Low-extractable thioxanthones LAMBERTI SPA (IT) 2015-01-13 US disclosed
EP-2359943-B1 ULTRA-THIN PHOTO-POLYMERIC COATINGS AND USES THEREOF SURMODICS INC (US) 2014-01-22 EP disclosed
US-8632877-B2 Ultra-thin photo-polymer coatings and uses thereof SURMODICS, INC. (US) 2014-01-21 US disclosed
EP-2638027-A1 LOW-EXTRACTABLE THIOXANTHONES Lamberti SpA (IT) 2013-09-18 EP disclosed
US-20130237628-A1 LOW-EXTRACTABLE THIOXANTHONES IGM RESINS ITALIA S.R.L. (IT) 2013-09-12 US disclosed
US-20130052456-A1 ULTRA-THIN PHOTO-POLYMER COATINGS AND USES THEREOF SURMODICS, INC. (US) 2013-02-28 US disclosed
US-8277928-B2 Ultra-thin photo-polymer coatings and uses thereof SURMODICS, INC. (US) 2012-10-02 US disclosed
WO-2012062692-A1 LOW-EXTRACTABLE THIOXANTHONES LAMBERTI SPA (IT) 2012-05-18 WO disclosed
US-8105666-B2 Compliant polymeric coatings for insertable medical articles BANK OF MONTREAL, AS COLLATERAL AGENT 2012-01-31 US disclosed
US-20050136091-A1 Crosslinkable macromers Surmodics Coatings, LLC 2005-06-23 US disclosed
EP-1063975-B1 CROSSLINKABLE MACROMERS BEARING INITIATOR GROUPS SURMODICS INC (US) 2005-05-18 EP disclosed
EP-1395301-A1 CROSSLINKABLE MACROMERS SurModics, Inc. (US) 2004-03-10 EP disclosed
US-20030031697-A1 Crosslinkable macromers Surmodics Coatings, LLC 2003-02-13 US disclosed
WO-2002100453-A1 CROSSLINKABLE MACROMERS SURMODICS, INC. (US) 2002-12-19 WO disclosed
US-6410044-B1 Crosslinkable macromers SURMODICS, INC. 2002-06-25 US disclosed
EP-1063975-A1 CROSSLINKABLE MACROMERS BEARING INITIATOR GROUPS SurModics, Inc. (US) 2001-01-03 EP disclosed
US-6156345-A Crosslinkable macromers bearing initiator groups SURMODICS, INC. (US) 2000-12-05 US disclosed
US-6007833-A RESIN MIXTURE HAVING IMPROVED NONTOXICITY, POLYMERIZATION EFFICIENCY, AND SOLUBILITY WHICH FORMS BIODEGRADABLE MATRIX FOR MEDICAL APPLICATION SURMODICS, INC. (US) 1999-12-28 US disclosed
WO-1999047129-A1 CROSSLINKABLE MACROMERS BEARING INITIATOR GROUPS SURMODICS, INC. (US) 1999-09-23 WO disclosed