Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR known ✓ | P02766 | 2/20 | 0.38 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473687 | 0.99 | BCL2L1 (0.46) | ALDH1A1KDM4EHPGDPOLBBCL2L1 | |
| SCHEMBL4200676 | 0.91 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDPOLBBCL2L1 | |
| SCHEMBL11240719 | 0.88 | BCL2L1 (0.49) | ALDH1A1KDM4EHPGDBCL2L1MCL1 | |
| SCHEMBL28456827 | 0.88 | STS (0.45) | ALDH1A1KDM4EHPGDSMN1; SMN2NPC1 | |
| SCHEMBL487121 | 0.86 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDPOLBBCL2L1 | |
| SCHEMBL28456554 | 0.84 | TTR (0.49) | ALDH1A1KDM4EHPGDPOLBSMN1; SMN2 | |
| SCHEMBL4541593 | 0.83 | CMA1 (0.48) | ALDH1A1KDM4EHPGDPOLBNPC1 | |
| SCHEMBL31314634 | 0.83 | CMA1 (0.48) | ALDH1A1KDM4EHPGDPOLBNPC1 | |
| SCHEMBL14985633 | 0.83 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDPOLBBCL2L1 | |
| SCHEMBL50803 | 0.81 | CA12 (0.44) | ALDH1A1KDM4EHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2359943-B1 | ULTRA-THIN PHOTO-POLYMERIC COATINGS AND USES THEREOF | SURMODICS INC (US) | 2014-01-22 | — | — | EP | disclosed |
| US-8632877-B2 | Ultra-thin photo-polymer coatings and uses thereof | SURMODICS, INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-20130052456-A1 | ULTRA-THIN PHOTO-POLYMER COATINGS AND USES THEREOF | SURMODICS, INC. (US) | 2013-02-28 | — | — | US | disclosed |
| US-8277928-B2 | Ultra-thin photo-polymer coatings and uses thereof | SURMODICS, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8105666-B2 | Compliant polymeric coatings for insertable medical articles | BANK OF MONTREAL, AS COLLATERAL AGENT | 2012-01-31 | — | — | US | disclosed |
| EP-2359943-A1 | ULTRA-THIN PHOTO-POLYMERIC COATINGS AND USES THEREOF | SurModics, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| EP-1945380-B1 | ULTRA-THIN PHOTO-POLYMERIC COATINGS AND USES THEREOF | SURMODICS INC (US) | 2011-02-16 | — | — | EP | disclosed |
| US-20100096320-A1 | Ultra-thin photo-polymer coatings and uses thereof | SURMODICS, INC. | 2010-04-22 | — | — | US | disclosed |
| US-7547445-B2 | Crosslinkable macromers | SURMODICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| EP-1945380-A2 | ULTRA-THIN PHOTO-POLYMERIC COATINGS AND USES THEREOF | SurModics, Inc. (US) | 2008-07-23 | — | — | EP | disclosed |
| US-20050136091-A1 | Crosslinkable macromers | Surmodics Coatings, LLC | 2005-06-23 | — | — | US | disclosed |
| EP-1063975-B1 | CROSSLINKABLE MACROMERS BEARING INITIATOR GROUPS | SURMODICS INC (US) | 2005-05-18 | — | — | EP | disclosed |
| EP-1395301-A1 | CROSSLINKABLE MACROMERS | SurModics, Inc. (US) | 2004-03-10 | — | — | EP | disclosed |
| US-20030031697-A1 | Crosslinkable macromers | Surmodics Coatings, LLC | 2003-02-13 | — | — | US | disclosed |
| WO-2002100453-A1 | CROSSLINKABLE MACROMERS | SURMODICS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |
| US-6410044-B1 | Crosslinkable macromers | SURMODICS, INC. | 2002-06-25 | — | — | US | disclosed |
| EP-1063975-A1 | CROSSLINKABLE MACROMERS BEARING INITIATOR GROUPS | SurModics, Inc. (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6156345-A | Crosslinkable macromers bearing initiator groups | SURMODICS, INC. (US) | 2000-12-05 | — | — | US | disclosed |
| US-6007833-A | RESIN MIXTURE HAVING IMPROVED NONTOXICITY, POLYMERIZATION EFFICIENCY, AND SOLUBILITY WHICH FORMS BIODEGRADABLE MATRIX FOR MEDICAL APPLICATION | SURMODICS, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| WO-1999047129-A1 | CROSSLINKABLE MACROMERS BEARING INITIATOR GROUPS | SURMODICS, INC. (US) | 1999-09-23 | — | — | WO | disclosed |