Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28692684 | 0.87 | LMNA (0.53) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL436082 | 0.85 | LMNA (0.51) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL28692686 | 0.85 | LMNA (0.51) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL11731699 | 0.84 | LMNA (0.47) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL11725915 | 0.81 | LMNA (0.47) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL26974831 | 0.79 | LMNA (0.45) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL11629193 | 0.78 | LMNA (0.54) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| Hydrochloric Acid SCHEMBL29682265 | 0.78 | LMNA (0.44) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL14582812 | 0.77 | LMNA (0.53) | LMNAALDH1A1L3MBTL1POLBTDP1 | |
| SCHEMBL1134756 | 0.76 | LMNA (0.56) | LMNAALDH1A1L3MBTL1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111153946-B | N-azido acetyl-D-mannosamine derivative, preparation method thereof and application thereof in detection of nitroreductase | 中国科学院化学研究所 | 2021-08-17 | — | — | CN | disclosed |
| CN-111153946-A | N-azido acetyl-D-mannosamine derivative, preparation method thereof and application thereof in detection of nitroreductase | 中国科学院化学研究所 | 2020-05-15 | — | — | CN | disclosed |
| US-20080145372-A1 | Bioreductively-Activated Prodrugs | ANGIOGENE, PHARMACEUTICALS LIMITED (GB) | 2008-06-19 | — | — | US | disclosed |
| WO-2007137196-A2 | TUBULIN BINDING ANTI CANCER COMPOUNDS AND PRODRUGS THEREOF | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| EP-1799698-A1 | BIOREDUCTIVELY-ACTIVATED PRODRUGS | Angiogene Pharmaceuticals Limited (GB) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032921-A1 | BIOREDUCTIVELY-ACTIVATED PRODRUGS | ANGIOGENE PHARMACEUTICALS LIMITED (GB) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080145372-A1 | Bioreductively-Activated Prodrugs | NME2, PNP, NUDT1 | LMNA 1716/4885ALDH1A1 219/4885L3MBTL1 3636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.