Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | GPR6 | P46095 | 2/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4871335 | 1.00 | HTR1A (0.34) | HTR1ASLC6A2SLC6A4MAPK14MAPK13 | |
| SCHEMBL4879098 | 0.94 | MAPK14 (0.37) | HTR1ASLC6A2SLC6A4MAPK14MAPK13 | |
| SCHEMBL4868872 | 0.94 | GPR6 (0.34) | HTR1ASLC6A2SLC6A4MAPK14MAPK13 | |
| SCHEMBL4868877 | 0.94 | GPR6 (0.34) | HTR1ASLC6A2SLC6A4MAPK14MAPK13 | |
| SCHEMBL4879095 | 0.94 | MAPK14 (0.37) | HTR1ASLC6A2SLC6A4MAPK14MAPK13 | |
| SCHEMBL4875589 | 0.94 | TP53 (0.32) | TP53THRBTLR8GPR6 | |
| SCHEMBL4877369 | 0.94 | TP53 (0.32) | TP53THRBTLR8GPR6 | |
| SCHEMBL4875579 | 0.94 | TP53 (0.32) | TP53THRBTLR8GPR6 | |
| SCHEMBL4879060 | 0.94 | HTR1A (0.32) | HTR1ASLC6A2SLC6A4NPC1RAB9A | |
| SCHEMBL4879052 | 0.94 | HTR1A (0.32) | HTR1ASLC6A2SLC6A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081825-A1 | Nitrogen-Containing Heterocyclic Compounds and Medicinal Use Thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-04-03 | — | — | US | disclosed |
| EP-1741702-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081825-A1 | Nitrogen-Containing Heterocyclic Compounds and Medicinal Use Thereof | MAPK1, NOS1, NOS2 | HTR1A 3509/4885SLC6A2 1777/4885SLC6A4 2262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.