Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.74 |
| ▸ | GAA | P10253 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 9/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 6/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23192329 | 0.78 | MAPT (0.52) | MAPTMAPK1RAB9AALDH1A1NPC1 | |
| SCHEMBL22952588 | 0.73 | MAPT (0.50) | MAPTMAPK1RAB9AALDH1A1NPC1 | |
| SCHEMBL16273457 | 0.71 | RAB9A (0.76) | MAPTMAPK1RAB9AALDH1A1NPC1 | |
| SCHEMBL14678567 | 0.69 | AR (0.62) | MAPTMAPK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6628766 | 0.69 | AR (0.58) | MAPTMAPK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28911465 | 0.66 | SIRT5 (1.00) | SIRT5G6PD | |
| SCHEMBL16273452 | 0.66 | SIRT5 (0.56) | MAPTMAPK1RAB9ANPC1L3MBTL1 | |
| SCHEMBL16273555 | 0.66 | MAPT (1.00) | MAPTMAPK1RAB9AALDH1A1NPC1 | |
| SCHEMBL2405184 | 0.66 | RAB9A (0.71) | MAPTRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL8799905 | 0.66 | AR (0.62) | MAPTMAPK1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411526-A2 | GANGLIOSIDE BIOSYNTHESIS MODULATORS | Zacharon Pharmaceuticals, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20100248365-A1 | GANGLIOSIDE BIOSYNTHESIS MODULATORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100248365-A1 | GANGLIOSIDE BIOSYNTHESIS MODULATORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| WO-2010111711-A2 | GANGLIOSIDE BIOSYNTHESIS MODULATORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100248365-A1 | GANGLIOSIDE BIOSYNTHESIS MODULATORS | UGCG, MAGT1, STT3B | MAPT 4120/4885MAPK1 2673/4885RAB9A 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.