Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.43 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22290 | 0.87 | — | — | |
| SCHEMBL17503288 | 0.87 | — | — | |
| SCHEMBL11674817 | 0.85 | TSHR (0.50) | TSHRGABRR1SLC6A1SLC6A13GABRP | |
| Ammonia Solution, Strong SCHEMBL8678266 | 0.85 | — | — | |
| SCHEMBL11674811 | 0.85 | TSHR (0.50) | TSHRGABRR1SLC6A1SLC6A13GABRP | |
| Acrylic Acid SCHEMBL1008091 | 0.84 | LMNA (0.46) | TSHRGABRR1SLC6A1SLC6A13GABRP | |
| Maleic Acid SCHEMBL725011 | 0.80 | TSHR (0.38) | TSHRSLC6A1SLC6A13TP53EGLN1 | |
| Acetic Acid SCHEMBL8598462 | 0.80 | TSHR (0.47) | TSHRGABRR1SLC6A1SLC6A13GABRP | |
| Vinyl Chloride SCHEMBL11168338 | 0.79 | TSHR (0.42) | TSHRGABRR1SLC6A1SLC6A13GABRP | |
| Sulfuric Acid SCHEMBL11001981 | 0.78 | TSHR (0.45) | TSHRGABRR1SLC6A1SLC6A13GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10250238-A | — | — | None | — | — | JP | disclosed |
| US-20080286512-A1 | MULTILAYERED LAMINATE FOR TUBES HAVING AN EMBEDDED ALUMINUM LAYER, A PROCESS FOR THE PRODUCTION THEREOF AND A TUBE PRODUCED THEREFROM | HUHTAMAKI RONSBERG ZWEIGNIEDERLASSUNG DER HUHTAMAKI DEUTSCHLAND GMBH & CO. KG (DE) | 2008-11-20 | — | — | US | disclosed |
| JP-H10250238-A | REWRITING TYPE THERMAL SHEET | TOSHIBA CORP | 1998-09-22 | — | — | JP | disclosed |